Fig. 1

Expression of p53 in primary ovarian cancer cells. The anti-p53 antibody used (polyclonal antibody #9282) binds strongly to the N-terminus and weakly to the DNA-binding region of p53. * = stop codon, hom. = homozygous. het. = heterozygous. It should be noted that the sequencing method used cannot distinguish between homozygous and hemizygous mutations. “het.” indicates that both wild type p53 and mutant p53 are found in the sample, which can either be due to heterozygosity or heterogeneity in the sample with the presence of cells with different p53 status