Ascites sample | Diagnosis | Histological description | Prior chemo-therapy | Platinum sensitivity | IC50 APR-246 (μM) | IC50 cisplatin (μM) | p53 status | p53 protein levels | Combination APR-246 cisplatin |
---|---|---|---|---|---|---|---|---|---|
1 | Ovarian cancer stage III | Poorly differentiated serous carcinomaa | Yes | Resistant | 25 | 40* | R280K (hom.) | ++ | SS |
2 | Cancer peritonei stage IV | Serous carcinoma | Yes | Resistant | 24 | 18 | wt | − | S, Add |
3 | Ovarian cancer stage IC | Serous carcinoma | Yes | Resistant | 37 | 32 | L111Q (het.) | + | S, SS |
4 | Ovarian cancer/Cancer peritonei stage IV | Poorly differentiated serous carcinomaa | Yes | Resistant | 18 | 3.2 | P151H (het.) | + | SS |
5 | Cancer peritonei stage IIIC | Serous adenocarcinoma, grade IIIa | No | Sensitive | 22 | 16 | C135Y (hom.) | + | SS |
6 | Tubar cancer stage IIIB | Poorly differentiated serous adenocarcinomaa | Yes | Sensitive | 12 | 17 | C238F (het.) | ++ | SS |
7 | Ovarian cancer stage IIIC | Poorly differentiated serous carcinomaa | Yes | Resistant | 56d | 45d | E346* (het.) | − | S, Add |
8 | Cancer Peritonei stage IV | Poorly differentiated serous carcinomaa | No | Sensitive | 8.9 | 7.1 | E204* (hom.) | − | SS |
9 | Ovarian cancer stage IIIC | Poorly differentiated serous carcinomaa | Yes | Resistant | 5.2 | 7.9 | P278R (hom.) | + | SS |
10 | Ovarian cancer stage IIIC | Medium-well differentiated serous adenocarcinomaa,b | Yes | Sensitive | 8.0 | 17 | Y163H (het.) | + | SS |