Table 1 Genes differentially expressed between SKOV3-NV and SKOV3-C1 (vehicle treated). SKOV3-NV and SKOV3-C1 cells were treated with vehicle (DMSO) for 24 h (n = 3/group). RNA was isolated and Affymetrix HTA 2.0 arrays were performed to determine differences in gene expression between SKOV3-NV and SKOV3-C1 cells. The top fifteen annotated, protein-coding genes (p < .05) in either direction are listed below
From: HE4 promotes collateral resistance to cisplatin and paclitaxel in ovarian cancer cells
Genes differentially expressed between SKOV3-NV and SKOV3-C1 (vehicle treated) | |||
|---|---|---|---|
Gene symbol | Description | Fold change (NV/C1) | ANOVA p-value |
CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | 14.95 | .000009 |
LAPTM5 | Lysosomal protein transmembrane 5 | 12.8 | 2.58E-08 |
ANPEP | Alanyl (membrane) aminopeptidase | 12.09 | 1.27E-08 |
NMUR2 | Neuromedin U receptor 2 | 11.96 | .000004 |
EPHA7 | EPH receptor A7 | 6.69 | .000015 |
PKP2 | Plakophilin 2 | 5.56 | .000008 |
SLC43A3 | Solute carrier family 43, member 3 | 5 | .000012 |
ACSM3 | Acyl-CoA synthetase medium-chain family member 3 | 4.62 | .00002 |
POF1B | Premature ovarian failure, 1B | 3.98 | .000026 |
CTH | Cystathionase (cystathionine gamma-lyase) | 3.76 | .000036 |
ALPK2 | Alpha-kinase 2 | 3.55 | .000021 |
KCTD4 | Potassium channel tetramerisation domain containing 4 | 3.47 | .000099 |
EREG | Epiregulin | 3.42 | .000006 |
DPP4 | Dipeptidyl-peptidase 4 | 3.31 | .000635 |
IL1A | (interleukin 1, alpha) | 3.19 | 0.000206 |
AKT3 | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | -4.03 | .000163 |
RRAGD | Ras-related GTP binding D | -4.06 | .000313 |
PSG3 | Pregnancy specific beta-1-glycoprotein 3 | -4.09 | 2.66E-07 |
POPDC3 | Popeye domain containing 3 | -4.18 | .000124 |
SH3BGRL2 | SH3 domain binding glutamic acid-rich protein like 2 | -4.29 | .000331 |
OLFM2 | Olfactomedin 2 | -4.33 | .002074 |
DPYSL5 | Dihydropyrimidinase-like 5 | -4.48 | .000457 |
SEPT3 | Septin 3 | -4.57 | .000203 |
S1PR1 | Sphingosine-1-phosphate receptor 1 | -4.6 | .000134 |
DSC3 | Desmocollin 3 | -5.13 | .000179 |
GPC4 | Glypican 4 | -5.22 | .000063 |
ADAM23 | ADAM metallopeptidase domain 23 | -5.53 | .000245 |
PDE3B | Phosphodiesterase 3B, cGMP-inhibited | -6.63 | .000081 |
PSG1 | Pregnancy specific beta-1-glycoprotein 1 | -6.73 | .000064 |
CYP24A1 | Cytochrome P450, family 24, subfamily A, polypeptide 1 | -7.34 | .000053 |