Table 2 Genes differentially expressed between SKOV3-NV and SKOV3-C1 (Cisplatin Treated). SKOV3-NV and SKOV3-C1 cells were treated with vehicle (DMSO) or 25 μM cisplatin for 24 h (n = 3/group). RNA was isolated and Affymetrix HTA 2.0 arrays were performed to determine differences in gene expression between SKOV3-NV and SKOV3-C1 cells. The top fifteen protein-coding, annotated genes with ≥1.5-fold change (p < 0.05) in either direction (excluding those genes that were already differentially expressed in vehicle treated cells) are listed below
From: HE4 promotes collateral resistance to cisplatin and paclitaxel in ovarian cancer cells
Genes differentially expressed between SKOV3-NV and SKOV3-C1 (Cisplatin Treated) | |||
|---|---|---|---|
Gene symbol | Description | Fold change (NV/C1) | ANOVA p-value |
EGR1 | Early growth response 1 | 4.07 | .000201 |
GDF15 | Growth differentiation factor 15 | 2.74 | .00056 |
ARL14 | ADP-ribosylation factor-like 14 | 2.72 | .000978 |
HIST2H4B | Histone cluster 2, H4b | 2.63 | 0.005913 |
ZNF280A | Zinc finger protein 280A | 2.16 | .003044 |
SNAI1 | Snail family zinc finger 1 | 2.03 | .003606 |
DDIT3 | DNA-damage-inducible transcript 3 | 1.98 | .000087 |
RND1 | Rho family GTPase | 1.91 | .003688 |
IDI2 | Isopentenyl-diphosphate delta isomerase 2 | 1.91 | .004807 |
TNF | Tumor necrosis factor | 1.9 | 0.017979 |
ULBP2 | UL16 binding protein 2 | 1.89 | .001767 |
IL6 | Interleukin 6 | 1.87 | .000493 |
CCL20 | Chemokine (C-C motif) ligand 20 | 1.86 | 0.000585 |
RAET1L | Retinoic acid early transcript 1Â L | 1.84 | 0.000244 |
PPP1R15A | (protein phosphatase 1, regulatory subunit 15A) | 1.83 | .001381 |
KDM6A | (lysine (K)-specific demethylase 6A) | -1.94 | .006738 |
MYO9A | Myosin IXA | -1.94 | 0.002316 |
CCBE1 | Collagen and calcium binding EGF domains 1 | -1.94 | 0.001091 |
GLDC | Glycine dehydrogenase (decarboxylating) | -1.96 | 0.001179 |
RHOT1 | Ras homolog family member T1 | -1.96 | 0.001224 |
THBS1 | Thrombospondin 1 | -1.96 | 0.002038 |
APOO | Apolipoprotein O | -1.97 | .001363 |
RNA5SP423 | Ribosomal protein S6 kinase, 90Â kDa, polypeptide 3 | -2.05 | .004154 |
RPS6KA3 | Ribosomal protein S6 kinase, 90Â kDa, polypeptide 3 | -2.05 | .004154 |
TBL1X | Transducin (beta)-like 1X-linked | -2.1 | .002705 |
CDH6 | Cadherin 6, type 2, K-cadherin (fetal kidney) | -2.11 | .00019 |
USP9X | Ubiquitin specific peptidase 9, X-linked | -2.12 | .003764 |
PDK3 | Pyruvate dehydrogenase kinase, isozyme 3 | -2.17 | .001499 |
BRWD3 | Bromodomain and WD repeat domain containing 3 | -2.27 | .004584 |
ARL14EPL | ADP-ribosylation factor-like 14 effector protein-like; laeverin | -2.33 | .002723 |