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Table 3 Factors associated with post-surgical adverse DOR at 3 months after laparoscopic cystectomy

From: Evaluation of factors predicting diminished ovarian reserve before and after laparoscopic cystectomy for ovarian endometriomas: a prospective cohort study

  Univariate analysis Multivariate analysis
Adverse DOR (n = 38) Non-adverse DOR (n = 74) P value OR (95 % CI) P value
Patient characteristics
 Age (years) 34.9 ± 5.0 (33.2–36.5) 32.8 ± 4.8 (31.7–33.9) 0.04
 Gravidity (%) 0.2 ± 0.6 (0.01–0.4) 0.1 ± 0.9 (0.04–0.2) 0.67   
 Parity (%) 0.2 ± 0.5 (0.2–0.3) 0.1 ± 0.3 (0.01–0.2) 0.47   
 Body mass index (kg/m2) 21.8 ± 4.6 (20.2–23.3) 21.3 ± 5.2 (20.1–22.5) 0.67   
Laterality of cysts
 Unilateral (%) 13 (34.2) 51 (68.9) <0.001 4.7 (1.93–11.5) 0.001
 Bilateral (%) 25 (65.8) 23 (31.1)    
 Total size of ovarian cyst (mm) 79.9 ± 35.0 (68.4–91.4) 69.6 ± 22.2 (64.4–74.7) 0.06   
Pre-surgical serum hormone concentrations
 LH (mIU/mL) 4.5 ± 4.0 (3.2–5.8) 7.0 ± 10.0 (4.7–9.3) 0.13   
 FSH (mIU/mL) 6.4 ± 2.6 (5.6–7.3) 6.5 ± 3.9 (5.6–7.4) 0.96   
 Estradiol (pg/mL) 79.4 ± 93.3 (48.7–110.1) 68.7 ± 84.3 (49.1–88.2) 0.54   
 CA125 (U/mL) 65.5 ± 44.2 (50.9–80.0) 70.6 ± 57.1 (57.4–83.9) 0.63   
 AMH (ng/mL) 2.8 ± 1.7 (2.2–3.4) 4.6 ± 3.1 (3.9–5.3) 0.001 0.65 (0.48–0.88) 0.005
Peri-surgical findings
 Re-ASRM score 60.9 ± 32.1 (50.4–71.4) 49.4 ± 27.5 (43.0–55.7) 0.05   
 Total surgical duration (min) 91.5 ± 40.8 (78.1–104.9) 81.9 ± 32.0 (74.5–89.3) 0.18   
 Total blood loss (mL) 40.2 ± 46.1 (25.0–55.3) 23.9 ± 26.8 (17.7–30.1) 0.02
  1. Abbreviations: AMH anti-Müllerian hormone, CA125 cancer antigen 125, CI confidence interval, DOR diminished ovarian reserve, FSH follicle-stimulating hormone, LH luteinising hormone, OR odds ratio, Re-ASRM revised American Society of Reproductive Medicine
  2. Data are expressed as mean ± standard deviation (95 % CI) or number (percentage) of patients