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Table 1 Correlation of topoisomerase isoenzymes with tumor grade of all EOC patients

From: Targeting of topoisomerases for prognosis and drug resistance in ovarian cancer

Topoisomerases Grades Case-low Case-high HR (% 95 CI) P-value
TOP1 I 20 38 2.07 (0.59 − 7.28) 0.25
  II 105 210 1.29 (0.9 − 1.85) 0.16
  III 405 563 1.3 (1.09 − 1.55) 0.0033
TOP2A I 38 18 2.79 (1.04 − 7.47) 0.033
  II 92 223 1.46 (1.07 − 1.98) 0.016
  III 275 693 1.21 (1.02 − 1.44) 0.028
TOP2B I 34 22 0.51 (0.18 − 1.41) 0.18
  II 200 115 1.48 (1.08 − 2.02) 0.014
  III 249 719 1.12 (0.92 − 1.36) 0.27
TOP3A I 36 20 0.48 (0.17 − 1.37) 0.16
  II 103 212 0.79 (0.58 − 1.09) 0.16
  III 670 298 0.8 (0.66 − 0.97) 0.021
TOP3B I 41 15 0.48 (0.14 − 1.69) 0.25
  II 137 178 1.25 (0.91 − 1.7) 0.16
  III 698 270 0.73 (0.6 − 0.88) 0.0012
  1. Abbreviation: HR hazard ratio; CI confidence interval