Targeting of topoisomerases for prognosis and drug resistance in ovarian cancer

Table 1 Correlation of topoisomerase isoenzymes with tumor grade of all EOC patients

Topoisomerases	Grades	Case-low	Case-high	HR (% 95 CI)	P-value
TOP1	I	20	38	2.07 (0.59 − 7.28)	0.25
	II	105	210	1.29 (0.9 − 1.85)	0.16
	III	405	563	1.3 (1.09 − 1.55)	0.0033
TOP2A	I	38	18	2.79 (1.04 − 7.47)	0.033
	II	92	223	1.46 (1.07 − 1.98)	0.016
	III	275	693	1.21 (1.02 − 1.44)	0.028
TOP2B	I	34	22	0.51 (0.18 − 1.41)	0.18
	II	200	115	1.48 (1.08 − 2.02)	0.014
	III	249	719	1.12 (0.92 − 1.36)	0.27
TOP3A	I	36	20	0.48 (0.17 − 1.37)	0.16
	II	103	212	0.79 (0.58 − 1.09)	0.16
	III	670	298	0.8 (0.66 − 0.97)	0.021
TOP3B	I	41	15	0.48 (0.14 − 1.69)	0.25
	II	137	178	1.25 (0.91 − 1.7)	0.16
	III	698	270	0.73 (0.6 − 0.88)	0.0012

ISSN: 1757-2215