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Table 3 Correlation of topoisomerase isoenzymes with TP53 status of all EOC patients

From: Targeting of topoisomerases for prognosis and drug resistance in ovarian cancer

Topoisomerases TP53 status Case-low Case-high HR (% 95 CI) P-value
TOP1 Mutated 109 303 0.83 (0.63−1.09) 0.18
  Wild type 54 32 1.91 (1.04−3.49) 0.033
TOP2A Mutated 278 161 1.32 (1.02−1.7) 0.036
  Wild type 30 56 0.74 (0.41−1.33) 0.31
TOP2B Mutated 252 187 0.78 (0.6−1.02) 0.066
  Wild type 38 48 1.34 (0.73−2.46) 0.34
TOP3A Mutated 300 139 1.17 (0.89−1.52) 0.26
  Wild type 63 23 0.68 (0.33−1.42) 0.3
TOP3B Mutated 304 135 1.26 (0.97−1.64) 0.086
  Wild type 42 44 1.45 (0.81−2.62) 0.21