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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: Developmental programming: rescuing disruptions in preovulatory follicle growth and steroidogenesis from prenatal testosterone disruption

Fig. 4

Mean (± SEM) intrafollicular steroid ratios of testosterone to estradiol (T: E2), T plus androstenedione (A4) to E2 (T + A4:E2), T + A4:estrone + E2, T:estrone + E2, and P4:E2 in 3 mm, 4 mm, and 5-6 mm follicles at the time of ovariectomy and coincidentally with the 8th FSH dose in control (C; yellow), prenatal testosterone-treated (T; red), prenatal T plus postnatal flutamide (T + F; blue), and prenatal T plus postnatal rosiglitazone (T + R; gray) females. See Fig. 1 for synchronization and controlled ovarian stimulation protocol and text for prenatal/postnatal treatment details. Within group comparisons, asterisks represent differences within group within hormone and between follicular sizes. Posthoc analyses performed only when overall ANOVA among all three sizes was significant. Data obtained from one 3 mm, one 4 mm, and two 5-6 mm follicles randomly selected from each female

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