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Table 2 The serum levels of HE4 and CA125 and ROMA values in the examined groups

From: Preoperative HE4, CA125 and ROMA in the differential diagnosis of benign and malignant adnexal masses

  Benign ovarian diseases Epithelial ovarian cancer p-value
Median (range) Median (range)
all patients
HE4 (pmol/l) 53.4 (22.1–328.6) 118.4 (37.4–1921.4) <0.001
CA125 (U/ml) 19.4 (4.2–150.3) 116.3 (14.4–3798.4) <0.001
ROMA (%) 12.4 (0.8–42.6) 50.4 (21.8–99.1) <0.001
premenopausal
HE4 (pmol/l) 50.4 (22.1–98.4) 84.1 (37.4–762.4) <0.001
CA125 (U/ml) 23.3 (4.2–150.3) 75.4 (14.4–706.2) <0.001
ROMA (%) 10.2 (0.8–35.8) 28.6 (21.8–85.6) <0.001
postmenopausal
HE4 (pmol/l) 56.4 (32.8–328.6) 147.8 (54.9–1921.4) <0.001
CA125 (U/ml) 12.3 (9.4–113.3) 168.7 (15.9–3798.4) <0.001
ROMA (%) 14.6 (1.2–42.6) 72.2 (30.2–99.1) <0.001