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Table 3 Diagnostic accuracy for discriminating between benign ovarian diseases and epithelial ovarian cancer

From: Preoperative HE4, CA125 and ROMA in the differential diagnosis of benign and malignant adnexal masses

BOD vs EOC Marker ROC-AUC (95 % CI) Cutoff optimal/preferred Sensitivity (%) optimal/preferred Specificity (%) optimal/preferred PPV (%) optimal/preferred NPV (%) optimal/preferred
all HE4 0.895 (0.838–0.951) 72.3 / 140 (pmol/l) 84.1 / 67.1 86.3 / 97.5 45.2 / 87.4 97.6 / 92.1
CA125 0.879 (0.818–0.941) 62.2 / 35 (U/ml) 83.1 / 81.9 82.4 / 74.1 41.6 / 36.9 93.9 / 96.2
ROMA 0.918 (0.853–0.938) 20.1 / 11.4; 29.9 (%) 86.2 / 84.8 86.8 / 88.2 39.4 / 36.3 94.4 / 96.6
pre-menopausal HE4 0.845 (0.806–0.894) 70.3 / 140 (pmol/l) 83.5 / 68.2 89.8 / 98.6 46.2 / 86.4 96.7 / 94.4
CA125 0.833 (0.753–0.944) 64.6 / 35 (U/ml) 87.0 / 86.6 84.1 / 70.9 44.8 / 33.6 94.8 / 96.1
ROMA 0.854 (0.778–0.876) 14.9 / 11.4 (%) 86.8 / 86.2 89.1 / 88.8 42.1 / 39.6 97.2 / 98.7
post-menopausal HE4 0.916 (0.841–0.979) 109.1 / 140 (pmol/l) 83.8 / 87.1 96.9 / 94.2 86.8 / 92.8 89.6 / 86.2
CA125 0.904 (0.855–0.943) 39.4 / 35 (U/ml) 84.1 / 91.9 96.7 / 89.8 91.7 / 83.2 92.8 / 94.4
ROMA 0.931 (0.898–0.959) 33.4 / 29.9 (%) 89.0 / 86.8 95.9 / 92.2 91.9 / 89.4 94.2 / 94.9
  1. BOD benign ovarian diseases, EOC epithelial ovarian cancer