From: MMP-14 and CD44 in Epithelial-to-Mesenchymal Transition (EMT) in ovarian cancer
Early-stage (n = 23) | Advanced-stage (n = 74) | p value* | |
---|---|---|---|
MMP-14 Overall Score (number of patients) | 0.07 | ||
0 | 8 | 11 | |
1 | 10 | 42 | |
MMP-14 stroma (number of patients) | 0.03 | ||
no | 4 | 25 | |
weak | 14 | 23 | |
strong | 0 | 5 | |
CD 44 Overall Score | 0 | ||
0 | 6 | 47 | |
1 | 15 | 21 | |
E-cadherin Overall Score | n.s. | ||
0 | 0 | 1 | |
1 | 21 | 67 | |
Vimentin epithelial score | 30 % | 32 % | n.s. |
Group with co-expression MMP-14-CD44a | 5 | 14 | |
Histological subtype | |||
Serous | 1 | 9 | |
Mucinous | 1 | 1 | |
Endometroid | 1 | 0 | |
Clear cell | 2 | 1 | |
Adenocarcinoma unspecified | 0 | 2 | |
Mixed | 0 | 1 | |
Grade | |||
Low-grade | 1 | 3 | |
High-grade | 4 | 11 | |
Debulking | |||
Complete | 11 | ||
Incomplete | 3 | ||
E-cadherin Overall Score | |||
0 | 0 | 1 | |
1 | 5 | 13 | |
Vimentin epithelial score | 36 % | 34 % |