Fig. 3
Pre-clinical analyses of LBH589 activity in vivo. Separate experiments utilizing PDXs derived from three individual patients are shown. Each evaluated the activity of LBH589 as a single agent and in combination with carboplatin and paclitaxel (P/C) chemotherapy. In all experiments, LBH589 induced statistically significant tumorstasis (p < 0.007, p < 0.03, p < 0.05). In one experiment (OV3), increased tumor regression was observed when LBH589 and P/C were combined (p < 0.02)