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Table 1 The basic characteristics of the included studies

From: Hypermethylated APC in serous carcinoma based on a meta-analysis of ovarian cancer

First author Country Ethnicity Method Sample Cancer LMP Benign Normal Low-grade High-grade StageI-II Stage III-IV Serous carcinoma Non-serous carcinoma
N (M %) N (M %) N (M %) N (M %) M/N M/N M/N M/N M/N M/N
Rathi 2002 [30] USA Caucasians MSP Tissue 49 (18.4) - 16 (0) - - - - - - -
Caceres 2004 [29] USA Caucasians MSP Tissue 35 (11.4) 10 (10) 10 (0) 10 (0) 0/12 4/23 1/8 3/27 2/21 2/14
Caceres 2004 [29] USA Caucasians MSP Blood 35 (8.6) 10 (10) 10 (0) 20 (0) 0/12 3/23 1/8 2/27 1/21 2/14
Makarla 2005 [28] USA Caucasians MSP Tissue 23 (21.7) 23 (0) 23 (0) 16 (0) - - - - 1/9 4/14
Tam 2007 [27] China Asians MSP Tissue 89 (47.2) 16 (50) 19 (26.3) 16 (25) - - - - - -
Wu 2007 [26] Norway Caucasians MSP Tissue 51 (23.5) 2 (0) 2 (0) - 7/26 5/23 9/25 3/26 3/19 9/27
Shen 2007 [31] China Asians MSP Tissue 63 (22.2) - - 30 (0) - - - - 4/34 10/29
Sun 2008 [32] China Asians MSP Tissue 59 (32.2) - - 42 (2.4) 5/36 14/23 2/21 17/38 11/30 8/29
Ho 2010 [25] China Asians MSP Tissue 63 (23.8) - 10 (0) 5 (0) - - - - 13/48 2/15
Bhagat 2012 [24] India Caucasians MSP Tissue 86 (29.1) 14 (28.6) 19 (15.8) 15 (0) 10/30 15/56 6/23 19/63 11/44 14/42
Zhang 2013 [23] China Asians MSP Blood 20 (35) - - 62 (0) - - - - - -
Brait 2013 [22] USA Caucasians QMSP Tissue 33 (15.1) - - 13 (0) - - - - - -
Al-Shabanah 2014 [21] Saudi Arabia Caucasians MSP Tissue 200 (36) - - 200 (10) - - 28/103 44/97 - -
  1. MSP methylation specific polymerase chain reaction, QMSP quantitative methylation specific PCR, M methylation, N the number of the total samples, “-” stands for data not applicable, LMP low malignant potential tumor