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Table 2 Summary of cell line cross-resistance to drug treatment

From: Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines

IC50 (nM)
Cell line CIS PAC DOX TOP
A2780 1.83 3.37 6.34 10.8
(0.94–3.14) (2.84–3.76) (5.76–7.04) (5.76–20.0)
1 1 1 1
A2780CR1 7,49 3.43 41.5 37.3
(5.39–8.72) (3.09–3.93) (32.8–48.0) (31.7–43.7)
4.09 ↑ * 1.01 6.54 ↑ ** 3.45
A2780CR2 6.03 3.86 6.84 8.59
(5.12–7.10) (3.13–4.48) (6.07–8.02) (8.09–9.11)
3.29 ↑ * 1.15 1.08 0.79
A2780DR1 1.79 283 367 37.3
(1.64–1.96) (123–601) (253–496) (33.5–41.0)
0.98 84 ↑ ** 58 ↑ ** 3.45
A2780DR2 2.32 569 461 30,9
(0.86–3.06) (407–983) (353–596) (22.1–38.6)
1.27 169 ↑ ** 73 ↑ ** 2.86
A2780TR1 0.84 4.13 46.4 644
(0.36–1.40) (3.56–4.65) (34.6–68.6) (350–851)
0.46 1.22 7.3 ↑ * 59.6 ↑ **
A2780TR2 4.24 40.5 192 523
(2.91–4.95) (24.7–56.6) (59.4–252) (409–616)
2.31 12 ↑ ** 30 ↑ * 48.5 ↑ **
A2780PR1 3.41 491 419 61.4
(1.86–4.57) (457–534) (384–464) (49.9–70.3)
1.86 146 ↑ ** 66 ↑ ** 5.68 ↑ *
A2780PR2 15.5 4052 22,673 1398
(9.31–22.4) (3872–4452) (29,757–14,104) (880–1913)
8.46 ↑ ** 1202 ↑ ** 3476 ↑ ** 129 ↑ **
  1. IC50 mean is indicated to each drug. The drug resistance in A2780 cell line was assigned as 1. ↑ Underline values indicate multiplicities of resistance with respect to A2780 cell line. *p < 0.01, **p < 0.001