IC50 (nM) | ||||
---|---|---|---|---|
Cell line | CIS | PAC | DOX | TOP |
A2780 | 1.83 | 3.37 | 6.34 | 10.8 |
(0.94–3.14) | (2.84–3.76) | (5.76–7.04) | (5.76–20.0) | |
1 | 1 | 1 | 1 | |
A2780CR1 | 7,49 | 3.43 | 41.5 | 37.3 |
(5.39–8.72) | (3.09–3.93) | (32.8–48.0) | (31.7–43.7) | |
4.09 ↑ * | 1.01 | 6.54 ↑ ** | 3.45 | |
A2780CR2 | 6.03 | 3.86 | 6.84 | 8.59 |
(5.12–7.10) | (3.13–4.48) | (6.07–8.02) | (8.09–9.11) | |
3.29 ↑ * | 1.15 | 1.08 | 0.79 | |
A2780DR1 | 1.79 | 283 | 367 | 37.3 |
(1.64–1.96) | (123–601) | (253–496) | (33.5–41.0) | |
0.98 | 84 ↑ ** | 58 ↑ ** | 3.45 | |
A2780DR2 | 2.32 | 569 | 461 | 30,9 |
(0.86–3.06) | (407–983) | (353–596) | (22.1–38.6) | |
1.27 | 169 ↑ ** | 73 ↑ ** | 2.86 | |
A2780TR1 | 0.84 | 4.13 | 46.4 | 644 |
(0.36–1.40) | (3.56–4.65) | (34.6–68.6) | (350–851) | |
0.46 | 1.22 | 7.3 ↑ * | 59.6 ↑ ** | |
A2780TR2 | 4.24 | 40.5 | 192 | 523 |
(2.91–4.95) | (24.7–56.6) | (59.4–252) | (409–616) | |
2.31 | 12 ↑ ** | 30 ↑ * | 48.5 ↑ ** | |
A2780PR1 | 3.41 | 491 | 419 | 61.4 |
(1.86–4.57) | (457–534) | (384–464) | (49.9–70.3) | |
1.86 | 146 ↑ ** | 66 ↑ ** | 5.68 ↑ * | |
A2780PR2 | 15.5 | 4052 | 22,673 | 1398 |
(9.31–22.4) | (3872–4452) | (29,757–14,104) | (880–1913) | |
8.46 ↑ ** | 1202 ↑ ** | 3476 ↑ ** | 129 ↑ ** |