|
IC50 (nM)
|
|---|
|
Cell line
|
CIS
|
PAC
|
DOX
|
TOP
|
|---|
|
A2780
|
1.83
|
3.37
|
6.34
|
10.8
|
|
(0.94–3.14)
|
(2.84–3.76)
|
(5.76–7.04)
|
(5.76–20.0)
|
|
1
|
1
|
1
|
1
|
|
A2780CR1
|
7,49
|
3.43
|
41.5
|
37.3
|
|
(5.39–8.72)
|
(3.09–3.93)
|
(32.8–48.0)
|
(31.7–43.7)
|
|
4.09 ↑ *
|
1.01
|
6.54 ↑ **
|
3.45
|
|
A2780CR2
|
6.03
|
3.86
|
6.84
|
8.59
|
|
(5.12–7.10)
|
(3.13–4.48)
|
(6.07–8.02)
|
(8.09–9.11)
|
|
3.29 ↑ *
|
1.15
|
1.08
|
0.79
|
|
A2780DR1
|
1.79
|
283
|
367
|
37.3
|
|
(1.64–1.96)
|
(123–601)
|
(253–496)
|
(33.5–41.0)
|
|
0.98
|
84 ↑ **
|
58 ↑ **
|
3.45
|
|
A2780DR2
|
2.32
|
569
|
461
|
30,9
|
|
(0.86–3.06)
|
(407–983)
|
(353–596)
|
(22.1–38.6)
|
|
1.27
|
169 ↑ **
|
73 ↑ **
|
2.86
|
|
A2780TR1
|
0.84
|
4.13
|
46.4
|
644
|
|
(0.36–1.40)
|
(3.56–4.65)
|
(34.6–68.6)
|
(350–851)
|
|
0.46
|
1.22
|
7.3 ↑ *
|
59.6 ↑ **
|
|
A2780TR2
|
4.24
|
40.5
|
192
|
523
|
|
(2.91–4.95)
|
(24.7–56.6)
|
(59.4–252)
|
(409–616)
|
|
2.31
|
12 ↑ **
|
30 ↑ *
|
48.5 ↑ **
|
|
A2780PR1
|
3.41
|
491
|
419
|
61.4
|
|
(1.86–4.57)
|
(457–534)
|
(384–464)
|
(49.9–70.3)
|
|
1.86
|
146 ↑ **
|
66 ↑ **
|
5.68 ↑ *
|
|
A2780PR2
|
15.5
|
4052
|
22,673
|
1398
|
|
(9.31–22.4)
|
(3872–4452)
|
(29,757–14,104)
|
(880–1913)
|
|
8.46 ↑ **
|
1202 ↑ **
|
3476 ↑ **
|
129 ↑ **
|
- IC50 mean is indicated to each drug. The drug resistance in A2780 cell line was assigned as 1. ↑ Underline values indicate multiplicities of resistance with respect to A2780 cell line. *p < 0.01, **p < 0.001
