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Table 1 Risk factors for gonadal damage in women undergoing HSCTa

From: Reproductive issues in patients undergoing Hematopoietic Stem Cell Transplantation: an update

Patient relating factor

 Pubertal stage

Postpuberal > prepuberal

 Age of HSCT

>30 years

 Underlying disease

ALL, lymphomas

Treatment relating factor

 Type of radiotherapy

TBI, pelvic, inverted Y, fractionated doses

 Chemotherapy

Alkylating agents > other chemotherapy

 Type of transplant

Allo-HSCT > auto-HSCT

 HSCT complications

Presence of GVHD

  1. ALL acute lymphoblastic leukaemia, allo allogeneic transplantation, auto autologous transplatation, GVHD graft-versus-host disease, HSCT hematopoietic stem cell transplant, TBI “total body” irradiation
  2. Symbol (>) means more than
  3. a modified from Orio et al. [4]