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Table 1 Descriptive data of all eligible studies regarding patients, their general features, type and indication for surgery and type/duration of infertilityIncluded

From: Salpingectomy before assisted reproductive technologies: a systematic literature review

Authors & Years

Type of Study

Patients (total)

Patients (Salpingectomy)

Patients-Controls

Age (year ± SD)

BMI (± SD)

Indication for Surgery

Time from Surgery

Reason of Infertility

Duration of Infertility

Lass et al. [1]

OP

102

a) 29 SLP (ECP)

Type: unilateral

Surgery: not specified

b) 73 no surgery

(healthy subjects)

a) 33.1 ± 4.9

b) 34.2 ± 4.1

n.r

a) ECP

2 years

a,b) MF 31; ID 42

2 years after surgery at least

Dechaud et al. [2]

RCT

60

a) 30 SLP (HY)

Type: not specified

Surgery: LPS

b) 30 diagnostic LPS

(TF, HY)

a) 31.7 ± 4.5

b) 30.6 ± 3.3

n.r

a,b) salpingitis or HY

a) 10.1 ± 7.5 months

b) 9.5 ± 7.2 months (LPS diagnostic)

a,b) TF

a) 55.2 ± 33.3 months

b) 48 ± 25.4 months

Bredkjaer et al. [3]

R

278

a) 139 SLP (HY)

Type: 128 bilateral, 11partial

Surgery: not specified

b) 139 no surgery

(TF, no HY)

a) 32.6 (22–39)

b) 32.9 (24–40)

n.r

a) HY

92 pz between 1.5 and 5 years

47 pz 3–6 months

a,b) TF

n.r

Strandell et al. [4]

RCT

204

a) 116 SLP (HY)

Type: not specified

Surgery: LPS

b) 88 no surgery

(TF, HY)

a) 31.8 ± 3.6

b) 31.8 ± 3.7

n.r

a,b) HY uni o bilateral

2 months (at least)

a,b) TF

1 month to 2 years

Dar et al. [5]

R

26

a) 26 SLP (ECP)

Type : 25 unilateral, 1 bilateral

Surgery: LPS

Control: same patients before surgery

a) 31.7 ± 3.6

n.r

a) ECP

a period < 3 years between the cycles (before and after surgery)

a) MEF 16; MF 6

AN 1; END 1; ID 2

n.r

Strandell et al. [6]

OP

26

a) 26 SLP (HY)

Type: 9 unilateral and 17 bilateral

Surgery: LPS

Control: same patients before surgery

a) 32.7 ± 3.6

n.r

a) HY

n.r

n.r

n.r

Strandell et al. [7]

RCT

185

a) 103 SLP (HY)

Type: 40 unilateral, 63 bilateral

Surgery: LPS

b) 82 no surgery

(TF, HY)

a) 32.8 ± 3.5

b) 32.5 ± 3.8

n.r

a) HY

n.r

a,b) TF

n.r

Surrey et al. [8]

R

94

a) 32 SLP (HY)

Type: not specified

Surgery: LPS

b) 15 PTO (HY)

c) 35 no surgery (TF no HY)

d) 12 tubal ligation (prior sterilization)

a) 35.1 ± 0.7

b) 35.4 ± 1.0

c) 35.6 ± 0.7

d) 38.2 ± 1.0

n.r

a,b) HY

c,d) TF

6 months

a,b,c,d) TF

n.r

Tal et al. [12]

OP

78

a) 26 SLP (ECP)

Type: unilateral

Surgery: 14 LPT, 12 LPS

b) 52 no surgery

(healthy subjects)

a) 32.1 ± 4.1

b) 32.0 ± 5.1

n.r

a) ECP

1-9 years

n.r

n.r

Chan et al. [13]

R

32

32 SLP (ECP)

a) 18 unilateral LPS

b) 14 unilateral LPT

Controls: non-operated site

a) 34 (31–38)

b) 36 (33–44)

a) 20.96

b) 21.44

a,b) ECP

3 months (at least)

n.r

n.r

Kontoravdis et al. [9]

RCT

115

a) 50 POT (HY)

b) 50 SLP (HY)

Type: not specified

Surgery: LPS

c) 15 no surgery (HY)

a) 31 ± 4.5

b) 29.8 ± 3.4

c) 34 ± 5.3

n.r

a,b) HY unilateral or bilateral

n.r

n.r

n.r

Gelbaya et al. [6]

R

168

a) 40 SLP (HY)

Type: 16 unilateral, 24 bilateral

b) 25 PTD

Type: 9 unilateral, 16 bilateral

Surgery: LPS

c) 103 no surgery

(tubal factor, no HY)

a) 32.8 ± 3.57

b) 33.1 ± 2.71

c) 33.5 ± 3.32

n.r

a,b) HY

3 months at least

All TF plus:

a) MF 2/40; OF 4/40; END 2/40

b) MF 5/25;OF 5/25; END 1/25

c) MF 12/103; OF 9/103; END 5/103

n.r

Moshin & Hotineanu [11]

RCT

204

a) 60 SLP (HY)

b) 78 PTO (HY)

Type: not specified

Surgery: not specified

c) 66 no surgery

(HY)

n.r

n.r

a,b) HY

n.r

n.r

n.r

Sezik et al. [16]

RCT

24

a) 12 total hysterectomy + bilateral- SLP

Surgery: LPT

b) 12 total hysterectomy without SLP

a) 41.6 ± 1.7

b) 41.1 ± 1.4

a) 24.5 ± 2.2

b) 26.6 ± 4.8

n.r

n.r

n.r

n.r

Nakagawa et al. [17]

P

17

a) 6 SLP (HY)

Type: not specified

Surgery: LPS

b) 11 PTD

(HY)

a) 31.7 ± 6.3

b) 35.3 ± 3.6

n.r

a,b) HY

n.r

n.r

n.r

Orvieto et al. [18]

R

15

a) 15 SLP (HY)

Type: not specified

Surgery: not specified

Controls: same patients before surgery

a) 32 ± 4.4

24 ± 5.5

a) HY

n.r

n.r

n.r

Almog et al. [19]

R

36

a) 36 SLP

Type :22 unilateral, 14 bilateral

Surgery: LPS

Controls: same patients before surgery

a) 34.2 ± 4.5

n.r

a) ECP 21

HY 14

Both 1

152 ± 36 days

n.r

n.r

Xi et al. [20]

R

156

a) 76 SLP (ECP)

Type: 32 bilateral, 44 unilateral (23 controlateral ligation)

Surgery: LPS

Controls: same patients before surgery

b) 80 no surgery

(healthy subjects)

a) 31.5 ± 4.2

n.r

a) ECP

At least 3 months after salpingectomy

a) TF 54

MF 7

END 5

n.r

Na et al. [21]

R

97

a) 41 SLP (HY)

Type: not specified

Surgery: LPS

b) 56 sclerotherapy (HY)

a) 32.4 ± 4.5

b) 32.9 ± 4.1

a) 22.2 ± 5.0

b) 21.5 ± 2.2

a, b) HY

n.r

a,b) HY

a) 3.8 ± 3.4

b) 2.9 ± 1.8

Ni et al.[22]

PC

134

60 SLP

a) 26 bilateral

b) 34 unilateral

c) 23 PTO

Surgery: LPS

d) 51 no surgery

(TF, no HY)

a) 29.23 ± 2.98

b) 30.12 ± 3.73

c) 30.65 ± 3.32

d) 29.18 ± 3.36

a) 21.21 ± 2.05

b) 21.37 ± 1.89

c) 20.78 ± 2.04

d) 20.95 ± 1.66

a, b) ECP, HY

c) HY

n.r

TF

n.s

a) 2.00 ± 1.67 years

b) 3.14 ± 2.12

c) 4.61 ± 2.81

d) 3.98 ± 2.44

Uyar et al. [23]

OP

162

a) 33 patients (ECP)

- 26 unilateral SLP

- 3 salpingostomy

- 1 tubal milkink

- 1 fimbriectomy

- 2 tubal abortion

surgery: LPS/LPT

b) 49 MTX (ECP)

c) 80 no surgery

a) 31.1 ± 5.1

b) 29.7 ± 5.0

c) 28.9 ± 6.0

n.r

a, b) ECP

n.r

n.r

n.r

Lin et al. [24]

R

288 cycles in 251 women

a) 103 cycles in 96 SLP Type: not specified

Surgery: LPS

b) 185 cycles in 155 women (prior sterilization, tuboplasty, PTO)

TF infertility

a) 33.2 ± 4.2

b) 32.8 ± 4.6

a) 22.1 ± 4.3

b) 21.9 ± 3.2

a) ECP or HY

n.a

a,b) TF

n.a

Grynnerup et al. [25]

P-CS

71

a) 16 SLP (HY)

Type: (uni/ bilateral)

not specified

Surgery: LPS

b) 42 no surgery (TF, with or without HY)

c) 13 no surgery (unexplained infertility, no HY)

a) 34 (25–37)

b) 33 (26–37)

c) 32 (27–36)

n.r

a) HY

At least 2 months

a) HY 16

b) TF 42

c) ID 13

a) 5 years

b) 4 years

c) 5 years

Findley et al. [26]

RCT

30

a) 15 hysterectomy + bilateral SLP

Surgery: LPS

b) 15 hysterectomy with no SLP

LPS

a) 36.6 ± 4.5

b) 37.8 ± 5.0

a) 34.4 ± 6.8

b) 38.1 ± 10.7

a,b) benign indications

n.r

n.r

n.r

Hill et al. [27]

R

189

a) 36 SLP (ECP)

Type: unilateral

Surgery: not specified

Controls: same patients before surgery

b) 153 MTX (ECP)

a) 35.8 ± 4.3

b) 34.3 ± 4.5

n.r

a,b) ECP

n.r

n.r

n.r

Ye et al. [28]

R

198

124 SLP (HY, ECP, TOA)

a) 83 unilateral

b) 41 bilateral

Surgery: not specified

c) 74 no surgery

(infertility, no TF)

a) 33,02 ± 4,66

b) 33,58 ± 3,95

c) 33,8 ± 4,67

a) 21,63 ± 2,46

b) 21,1 ± 2,85

c) 21,43 ± 2,83

a) ECP 79

HY 3

TOA 1

b) ECP 24

HY 16

TOA 1

n.r

a) MF 45;

MF & FF 28

b) MF 16

MF & FF 15

c) MF 38

MF & FF 26

UNKNOWN 2

a) 0.31 ± 1.13 PI

2.85 ± 2.81 SI

b) 0.82 ± 1.96 PI

3.23 ± 3.24 SI

c) 3.6 ± 4.15 PI

2.36 ± 3.32 SI

Pereira et al. [29]

R

144

a) 37 SLP (ECP)

Type: unilateral Surgery: LPS

b) 107 MTX (ECP)

Controls: same patients before surgery or MTX

a) 36.4 ± 3.03

b) 37.1 ± 4.01

a) 24 ± 3.65

b) 23.2 ± 4.23

a,b) ECP

12 months

a) A 31.8 %; TF 3 13.6 %; END 9 %; MF 18.1 %; ID 4.55 %; Other 18.1 %

b) AN 32.9 %;TF 12.5 %: END 7.95 %;

MF 23.9 % ID 5.68 %

Other 15.9 %

n.r

Odesjo et al. [30]

R

153

a) 118 SLP (ECP)

Type: unilateral

Surgery: not specified

b) 35 unilateral salpingotomy

(ECP)

a) 32.5 ± 3.93

b) 33.8 ± 3.07

a) 24.9 ± 4.5

b) 24 ± 3.76

a,b) ECP

a) 3.11 ± 2.90 years

b) 6.85 ± 5.05 years

a) TF 92 (78 %)

a) other reasons 26 (22 %)

b) TF 24 (70.6 %)

b) other reason 10 (29.4 %)

n.r

Venturella et al. [31]

RCT

186

a) 91 SLP standard

b) 95 SLP wide*

Type: bilateral

surgery: LPS

Controls: same patients before surgery

a) 41.16 ± 5.33

b) 41.56 ± 5.45

n.r

a,b) myomectomy,

tubal surgical sterilization

n.a

n.a

n.a

  1. SLP, salpingectomy; n.r, not reported; n.a, not applicable; ECP, ectopic pregnancy; HY, Hydrosalpinx; TOA, tubo-ovarian abscess; FF, female factor (n.s), TF, tubal factor; OF, ovarian factor; MF, male factor; END, Endometriosis; MEF, mechanical factor; AN, anovulation; ID, idiopathic; R, retrospective; OP, observational-prospective; RCT, randomized controlled trial; P-CS, prospective cross-sectional study; PC, prospective cohort study; LPS, laparoscopy; LPT, laparotomy; PTD, proximal tubal division; PTO, proximal tubal occlusion/ligation; MTX, methotrexate; PI, primary infertility; SI, secondary infertility