1. Most patients are usually younger.
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1. Most patients are postmenopausal, with a mean age of 62 years
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2. It is always reactive and secondary. Usually associated with underlying chronic inflammation or hyperestrogenic states
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2. It is always primary.
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3. It shows no gross evidence of tumor, but there is inflamed, grossly dilated or thickened tube.
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3. Most carcinomas are grossly evident.
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4. Chronic inflammation is marked.
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4. Chronic inflammation is not prominent.
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5. Solid epithelial proliferation is not observed.
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5. Solid epithelial proliferation is variably evident.
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6. Mild to moderate nuclear atypia is observed
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6. Nuclear atypia is prominent.
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7. There are few mitotic figures. It has been considered an important criterion.
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7. There are numerous mitotic figures.
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8. Invasion of the tubal wall is not evident, but pseudoinvasion of the muscularis by gland like structures or lymphatic penetration by epithelial cells can be observed.
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8. True invasion of the tubal wall is evident.
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