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Table 5 Effect of Rutin-I (100 mg/kg) and Rutin-II (150 mg/kg) on ROS, TBARS, LOOH, CAT, POD, SOD, GSR, GST, GSH, GSH-px concentrations in Letrozole induced PCOS rats after 36 days of experiment

From: Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats

Parameters Control PCOS Metformin Rutin-I Rutin-II
ROS (U/min) 0.20 ± 0.04 0.39 ± 0.09a* 0.17 ± 0.02b* 0.19 ± 0.02b* 0.16 ± 0.01b*
TBARS (nmol/min/mg) 5.69 ± 1.07 16.06 ± 1.25a** 10.78 ± 1.07 8.93 ± 2.45b* 8.15 ± 0.82b*
LOOH (nmol/min/mg) 3.29 ± 0.48 5.39 ± 0.29a* 3.44 ± 0.47 3.59 ± 0.63 3.23 ± 0.42b*
CAT(U/min) 4.93 ± 0.08 3.49 ± 0.33a* 4.15 ± 0.47 4.22 ± 0.28 4.49 ± 0.38
POD(nmole) 12.09 ± 0.72 9.29 ± 0.01a* 10.44 ± 0.62 10.11 ± 0.58 11.87 ± 0.59b*
SOD (U/min) 5.81 ± 0.24 2.74 ± 0.29a* 5.51 ± 0.51b* 5.41 ± 1.08b* 5.72 ± 0.51b*
GSR (U/mol/mg) 3.96 ± 0.38 1.79 ± 0.09a* 3.89 ± 0.29b* 3.46 ± 0.71 4.67 ± 0.52b*
GST (U/mol/mg) 10.85 ± 0.21 8.02 ± 0.83a** 9.47 ± 0.28 9.37 ± 0.48 10.91 ± 0.22b*
GSH (U/mol/mg) 6.91 ± 0.50 4.97 ± 0.14a** 6.55 ± 0.48b* 6.39 ± 0.02b* 6.77 ± 0.88b**
GSH-px (U/mol/mg) 29.87 ± 2.14 20.35 ± 0.64a** 25.34 ± 2.11 24.24 ± 1.76 30.10 ± 1.29b**
  1. Values are expressed as Mean ± SEM
  2. *=p< 0.05, **=p< 0.01
  3. aValue vs control, bValue vs PCOS