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Table 5 Effect of Rutin-I (100 mg/kg) and Rutin-II (150 mg/kg) on ROS, TBARS, LOOH, CAT, POD, SOD, GSR, GST, GSH, GSH-px concentrations in Letrozole induced PCOS rats after 36 days of experiment

From: Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats

Parameters

Control

PCOS

Metformin

Rutin-I

Rutin-II

ROS (U/min)

0.20 ± 0.04

0.39 ± 0.09a*

0.17 ± 0.02b*

0.19 ± 0.02b*

0.16 ± 0.01b*

TBARS (nmol/min/mg)

5.69 ± 1.07

16.06 ± 1.25a**

10.78 ± 1.07

8.93 ± 2.45b*

8.15 ± 0.82b*

LOOH (nmol/min/mg)

3.29 ± 0.48

5.39 ± 0.29a*

3.44 ± 0.47

3.59 ± 0.63

3.23 ± 0.42b*

CAT(U/min)

4.93 ± 0.08

3.49 ± 0.33a*

4.15 ± 0.47

4.22 ± 0.28

4.49 ± 0.38

POD(nmole)

12.09 ± 0.72

9.29 ± 0.01a*

10.44 ± 0.62

10.11 ± 0.58

11.87 ± 0.59b*

SOD (U/min)

5.81 ± 0.24

2.74 ± 0.29a*

5.51 ± 0.51b*

5.41 ± 1.08b*

5.72 ± 0.51b*

GSR (U/mol/mg)

3.96 ± 0.38

1.79 ± 0.09a*

3.89 ± 0.29b*

3.46 ± 0.71

4.67 ± 0.52b*

GST (U/mol/mg)

10.85 ± 0.21

8.02 ± 0.83a**

9.47 ± 0.28

9.37 ± 0.48

10.91 ± 0.22b*

GSH (U/mol/mg)

6.91 ± 0.50

4.97 ± 0.14a**

6.55 ± 0.48b*

6.39 ± 0.02b*

6.77 ± 0.88b**

GSH-px (U/mol/mg)

29.87 ± 2.14

20.35 ± 0.64a**

25.34 ± 2.11

24.24 ± 1.76

30.10 ± 1.29b**

  1. Values are expressed as Mean ± SEM
  2. *=p< 0.05, **=p< 0.01
  3. aValue vs control, bValue vs PCOS