Table 5 Correlation of molecular biomarker expression and chemotherapeutic response
Molecular biomarkers | HGSC | CCC | ||||
|---|---|---|---|---|---|---|
| Â | Platinum sensitive (%) | aPlatinum resistant (%) | HGSCP | Platinum sensitive (%) | aPlatinum resistant (%) | CCC P |
EGFR | Â | Â | 0.365 | Â | Â | 0.129 |
 Negative | 58(75.3) | 20(66.7) |  | 36(58.1) | 17(77.3) |  |
 Positive | 19(24.7) | 10(33.3) |  | 26(41.9) | 5(22.7) |  |
HER2 | Â | Â | 1.000 | Â | Â | 0.725 |
 Negative | 75(97.4) | 29(96.7) |  | 56(87.5) | 19(82.6) |  |
 Positive | 2(2.6) | 1(3.3) |  | 8(12.5) | 4(17.4) |  |
PTEN | Â | Â | 0.530 | Â | Â | 0.679 |
 Negative | 68(88.3) | 25(83.3) |  | 58(92.1) | 21(87.5) |  |
 Positive | 9(11.7) | 5(16.7) |  | 5(7.9) | 3(12.5) |  |
AURKA | Â | Â | 0.505 | Â | Â | 0.042 |
 Negative | 49(63.6) | 17(56.7) |  | 42(65.6) | 10(41.7) |  |
 Positive | 28(36.3) | 13(43.3) |  | 22(34.4) | 14(58.3) |  |
BRCA1 | Â | Â | 0.584 | Â | Â | 0.848 |
 Negative | 55(71.4) | 23(76.7) |  | 35(56.5) | 13(54.2) |  |
 Positive | 22(28.6) | 7(23.3) |  | 27(43.5) | 11(45.8) |  |
BRCA2 | Â | Â | 1.000 | Â | Â | 0.542 |
 Negative | 68(88.3) | 27(90.0) |  | 50(80.6) | 21(87.5) |  |
 Positive | 9(11.7) | 3(10.0) |  | 12(19.4) | 3(12.5) |  |
PD-L1 | Â | Â | 0.502 | Â | Â | 0.028 |
 Negative | 66(86.8) | 28(93.3) |  | 56(87.5) | 15(65.2) |  |
 Positive | 10(13.2) | 2(6.7) |  | 8(12.5) | 8(34.8) |  |