Fig. 1

The four human receptors Notch1, 2, 3, 4. Human have four receptors: Notch1, 2, 3, 4. The Notch receptor has an extracellular domain consisting of EGF-like repeats with three cysteine-rich Lin12 repeats and intracellular domain containing a RAM23 domain, six ankyrin repeats, a transactivation domain (TAD) and a PEST sequence. Two nuclear localization sequences are present prior to and following the ankyrin repeats. Of note, Notch 1–3 contain cytokine response sequences (NCR) and The TAD is absent in Notch 3 and Notch 4