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Table 5 Diagnostic performances of combined methods to detect malignancy at specific cut-off values

From: Reliability of preoperative evaluation of postmenopausal ovarian tumors

Developed method Sensitivity
%
95% CI Specificity
%
95% CI PPV
%
95% CI NPV
%
95% CI Accuracy
%
RMI > 200 and VFI > 0.31 51.6 33.1–69.9 95.5 87.3–99.1 84.2 60.4–96.6 80.8 70.3–88.8 81.4
Simple rules with expert opiniona and VFI > 0.31 71.0 52.0–85.8 95.5 87.3–99.1 88.0 68.8–97.5 87.5 77.6–94.1 86.7
LR2 > 25 and VFI > 0.31 64.5 45.4–80.8 97.0 89.5–99.6 90.9 70.8–98.9 85.3 75.3–92.4 86.5
  1. IOTA International Ovarian Tumor Analysis; CI Confidential interval; PPV Positive predictive value; NPV Negative predictive value; RMI Risk of malignancy index; VFI Vascularization flow index; LR2 Logistic regression model 2
  2. aTwo step-strategy: As a result of inconclusive by simple rules, the expert evaluates the tumor