Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort

Table 1 Population characteristics for controls included in cross sectional analysis of CA125, CA15.3, HE4, and CA72.4: EPIC ovarian cancer nested case-control study

Characteristic	Total sample n = 1910
Age at blood draw, mean (sd)	56.3 (8.3)
Age at menarche, mean (sd)	13.3 (1.6)
Ever OC use, n (%)	930 (50%)
OC duration among users, years, mean (sd)	8.5 (8.1)
Parous, n (%)	1573 (89%)
Number of children among parous, mean (sd)	2.4 (1.1)
Unilateral oophorectomy, n(%)	70 (4%)
Postmenopausal, n (%)	1421 (74%)
HT use among postmenopausal women	463 (33%)
BMI, kg/m², mean (sd)	25.8 (4.5)
Current smoker, n (%)	360 (19%)
Packyears of smoking among current smokers, mean (sd)	21.4 (13.5)
CA125 (U/mL), geometric mean (95% CI)	20.1 (19.6, 20.7)
CA15.3 (mU/mL), geometric mean (95% CI)	600.4 (585.7, 615.5)
HE4 (pM), geometric mean (95% CI)^a	18.9 (18.2, 19.5)
CA72.4 (U/mL), geometric mean (95% CI)^a	0.69 (0.66, 0.72)

Some participants had missing data: age at menarche (n = 78), oral contraceptive use (n = 57), duration of OC use (n = 66), parity (n = 136), number of children (n = 43), BMI (n = 94), smoking (n = 28), packyears among current smokers (n = 10), CA125 (n = 10), CA15.3 (n = 17), HE4 (n = 1197), CA72.4 (n = 1197)
^a Restricted to 713 controls with HE4/CA72.4 measurements. Note, participants with CA72.4 less than the limit of detection were assigned value of 0.56 (half of the limit of detection); geometric mean (95% CI) retricted to women with values above the limit of detection: 2.4 (2.0-2.9)

ISSN: 1757-2215