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Fig. 1 | Journal of Ovarian Research

Fig. 1

From: Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair

Fig. 1

Let-7e expression is significantly decreased in chemo-resistant epithelial ovarian cancer (EOC). a Representative images of let-7e via in situ hybridization in one of the chemo-resistant (upper) versus chemo-sensitive (down) ovarian cancer specimens. The positive let-7e LNA-ISH signal is blue. b The corresponding histogram of the semi-quantification of let-7e level in two groups. Mann Whitney test, ***P < 0.0001. c Validation of let-7e using qRT-PCR in seven ovarian cancer cell lines. C13K is the corresponding cisplatin-resistant variants of ovarian cancer cell OV2008. The let-7e level in A2780 were set as 1. Student’s t-test, **P < 0.01

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