Fig. 4

Expression of let-7e, BRCA1 and Rad51 in EOC. a Results of western bolt analysis of BRCA1 and Rad51 protein expression in cisplatin-sensitive and resistant cells. b Representative images of let-7e expression via ISH and BRCA1, Rad51 via IHC in one of the chemo-resistant or sensitive ovarian cancer tissues. The let-7e LNA-ISH signal is blue (black arrow) and IHC positive staining is yellow (red arrow). c Semi-quantification of BRCA1 and Rad51 expression in chemo-resistant versus chemo-sensitive EOC tissues. P _BRCA1  = 0.0251, P _Rad51  = 0.0001. d Expression of Rad51 and BRCA1 in let-7e high and low level cohort. P _BRCA1  = 0.0383, P _Rad51  = 0.0016. Mann Whitney test, *P < 0.05, **P < 0.01, ***P < 0.001