Fig. 5

Influence of let-7e, BRCA1 and Rad51 on predicting survival and sensitivity to chemotherapy in EOC. a–e Kaplan-Meier survival curves for EOC patients based on the expression of let-7e, Rad51 and BRCA1. a, PFS for let-7e; b, OS for let-7e; c, PFS for Rad51; d, OS for Rad51; e, PFS for BRCA1. Ovarian cancer patients were stratified into let-7e, Rad51 or BRCA1 low and high expression groups according to the mean scores of their expression. Log-rank test. f ROC curves of let-7e, Rad51, BRCA1 and the combination of low let-7e and high Rad51 (n = 58). AUC _let-7e  = 0.826, P < 0.0001; AUC _Rad51  = 0.783, P = 0.001; AUC _BRCA1  = 0.697, P = 0.019; AUC _{low let-7e/high Rad51}  = 0.846, P < 0.0001