Table 1 Associations of let-7e, BRCA1 and Rad51 expression with clinicopathological characteristics of EOC patients
Clinicopathological Features | No. of Cases | Let-7e expression No.(%) | No. of Cases | BRCA1 expression No.(%) | Rad51 expression No.(%) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Low | High | P Value a | Â | Low | High | P Value a | Low | High | P Value a |
Age at surgery, y | |||||||||||
 <50 | 25 | 10 (40.0) | 15 (60.0) | 1 | 26 | 11 (42.3) | 15 (57.7) | 0.800 | 11 (42.3) | 15 (57.7) | 0.126 |
 ≥50 | 40 | 15 (37.5) | 25 (62.5) |  | 39 | 19 (48.7) | 20 (51.3) |  | 25 (64.1) | 14 (35.9) |  |
Histological subtypes | |||||||||||
 Serous | 53 | 22 (41.5) | 31 (58.5) | 0.344 | 52 | 24 (46.2) | 28 (53.8) | 1 | 27 (51.9) | 25 (48.1) | 0.355 |
 Others | 12 | 3 (25.0) | 9 (75.0) |  | 13 | 6 (46.2) | 7 (53.8) |  | 9 (69.2) | 4 (30.8) |  |
FIGO stage | |||||||||||
 I–II | 17 | 5 (29.4) | 12 (70.6) | 0.563 | 18 | 9 (50.0) | 9 (50.0) | 0.784 | 13 (72.2) | 5 (27.8) | 0.104 |
 III–IV | 48 | 20 (41.7) | 28 (58.3) |  | 47 | 21 (44.7) | 26 (55.3) |  | 23 (48.9) | 24 (51.1) |  |
Tumor categories | |||||||||||
 Type I | 15 | 3 (20.0) | 12 (80.0) | 0.133 | 16 | 8 (50.0) | 8 (50.0) | 0.778 | 11 (68.7) | 5 (31.3) | 0.258 |
 Type II | 50 | 22 (44.0) | 28 (56.0) |  | 49 | 22 (44.9) | 27 (55.1) |  | 25 (51.0) | 24 (49.0) |  |
Chemotherapy response | |||||||||||
 Sensitive | 43 | 8 (18.6) | 35 (81.4) | <0.0001 | 46 | 26 (56.5) | 20 (43.5) | 0.013 | 33 (71.7) | 13 (28.3) | <0.0001 |
 Resistant | 22 | 17 (77.3) | 5 (22.7) |  | 19 | 4 (21.1) | 15 (78.9) |  | 3 (15.8) | 16 (84.2) |  |