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Table 2 Associations of different parameters with PFS, OS and chemotherapy response of EOC patients

From: Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair

  

PFS a

OS a

Case No. (%)

Chemotherapy response b

Variables

Case No. (%)

HR (95% CI)

P Value

HR (95% CI)

P Value

OR (95% CI)

P Value

Age at surgery, y

        

<50

25 (40.3)

0.921 (0.439–1.932)

0.828

0.763 (0.329–1.771)

0.529

23 (40.3)

1.094 (0.346–3.461)

0.879

≥50

37 (59.4)

1

 

1

 

35 (59.4)

1

 

Histological subtypes

        

Serous

50 (80.6)

1.493 (0.567–3.93)

0.417

1.153 (0.390–3.412)

0.796

46 (80.6)

2.419 (0.47–12.454)

0.291

Others

12 (19.4)

1

 

1

 

12 (19.4)

1

 

FIGO stage

        

I-II

18 (29.0)

0.352 (0.123–1.012)

0.053

0.143 (0.019–1.063)

0.057

16 (29.0)

0.257 (0.051–1.287)

0.098

III-IV

44 (71.0)

1

 

1

 

42 (71.0)

1

 

Tumor categories

        

Type I

15 (24.2)

0.647 (0.263–1.587)

0.341

0.762 (0.281–2.071)

0.595

15 (24.2)

0.518 (0.126–2.136)

0.363

Type II

47 (75.8)

1

 

1

 

43 (75.8)

1

 

Let-7e expression

        

Low

23 (37.1)

3.204 (1.541–6.661)

0.002

4.368 (1.804–10.575)

0.001

21 (37.1)

22.667 (5.114–100.457)

<0.0001

High

39 (62.9)

1

 

1

 

37 (62.9)

1

 

BRCA1 expression

        

Low

25 (40.3)

1

0.078

1

0.350

23 (40.3)

1

0.011

High

37 (59.7)

1.993 (0.925–4.294)

 

1.510 (0.636–3.585)

 

35 (59.7)

7.875 (1.594–38.906)

 

Rad51 expression

        

Low

32 (51.6)

1

0.001

1

0.025

30 (51.6)

1

0.001

High

30 (48.4)

3.584 (1.668–7.701)

 

2.752 (1.133–6.682)

 

28 (48.4)

16.154 (3.212–81.252)

 
  1. EOC epithelial ovarian cancer, HR hazards ratio, CI confidence interval, PFS progression-free survival, OS overall survival, OR odds ratio, FIGO International Federation of Gynecology and Obstetrics
  2. a Univariate Cox proportional hazards Regression analysis; b Univariate logistic regression analysis