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Table 2 Associations of different parameters with PFS, OS and chemotherapy response of EOC patients

From: Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair

   PFS a OS a Case No. (%) Chemotherapy response b
Variables Case No. (%) HR (95% CI) P Value HR (95% CI) P Value OR (95% CI) P Value
Age at surgery, y         
<50 25 (40.3) 0.921 (0.439–1.932) 0.828 0.763 (0.329–1.771) 0.529 23 (40.3) 1.094 (0.346–3.461) 0.879
≥50 37 (59.4) 1   1   35 (59.4) 1  
Histological subtypes         
Serous 50 (80.6) 1.493 (0.567–3.93) 0.417 1.153 (0.390–3.412) 0.796 46 (80.6) 2.419 (0.47–12.454) 0.291
Others 12 (19.4) 1   1   12 (19.4) 1  
FIGO stage         
I-II 18 (29.0) 0.352 (0.123–1.012) 0.053 0.143 (0.019–1.063) 0.057 16 (29.0) 0.257 (0.051–1.287) 0.098
III-IV 44 (71.0) 1   1   42 (71.0) 1  
Tumor categories         
Type I 15 (24.2) 0.647 (0.263–1.587) 0.341 0.762 (0.281–2.071) 0.595 15 (24.2) 0.518 (0.126–2.136) 0.363
Type II 47 (75.8) 1   1   43 (75.8) 1  
Let-7e expression         
Low 23 (37.1) 3.204 (1.541–6.661) 0.002 4.368 (1.804–10.575) 0.001 21 (37.1) 22.667 (5.114–100.457) <0.0001
High 39 (62.9) 1   1   37 (62.9) 1  
BRCA1 expression         
Low 25 (40.3) 1 0.078 1 0.350 23 (40.3) 1 0.011
High 37 (59.7) 1.993 (0.925–4.294)   1.510 (0.636–3.585)   35 (59.7) 7.875 (1.594–38.906)  
Rad51 expression         
Low 32 (51.6) 1 0.001 1 0.025 30 (51.6) 1 0.001
High 30 (48.4) 3.584 (1.668–7.701)   2.752 (1.133–6.682)   28 (48.4) 16.154 (3.212–81.252)  
  1. EOC epithelial ovarian cancer, HR hazards ratio, CI confidence interval, PFS progression-free survival, OS overall survival, OR odds ratio, FIGO International Federation of Gynecology and Obstetrics
  2. a Univariate Cox proportional hazards Regression analysis; b Univariate logistic regression analysis