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Table 3 Multivariate regression analysis of significant prediction factors on PFS,OS and chemotherapy response of EOC patients

From: Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair

   PFS a OS a   Chemotherapy response b
Variables Case No. (%) HR (95% CI) P Value HR (95% CI) P Value Case No. (%) OR (95% CI) P Value
FIGO stage
I–II 18 (29.0) 0.552 (0.184–1.658) 0.290 0.204 (0.027–1.551) 0.125 16 (29.0) - -
III–IV 44 (71.0) 1   1   42 (71.0)   
Let-7e expression         
Low 23 (37.1) 2.037 (0.912–4.554) 0.083 3.235 (1.258–8.317) 0.015 21 (37.1) 19.696 (3.477–111.572) 0.001
High 39 (62.9) 1   1   37 (62.9) 1  
BRCA1 expression         
Low 25 (40.3) - - - - 23 (40.3) 1 0.155
High 37 (59.7)      35 (59.7) 5.042 (0.541–47.011)  
Rad51 expression         
Low 32 (51.6) 1 0.029 1 0.404 30 (51.6) 1 0.163
High 30 (48.4) 2.519 (1.098–5.779)   1.500 (0.579–3.891)   28 (48.4) 4.290 (0.553–33.26)  
  1. EOC epithelial ovarian cancer, HR hazards ratio, CI confidence interval, PFS progression-free survival, OS overall survival, OR odds ratio, FIGO International Federation of Gynecology and Obstetrics
  2. a Multivariate Cox proportional hazards Regression analysis; b Multivariate logistic regression analysis