Skip to main content

Table 3 Multivariate regression analysis of significant prediction factors on PFS,OS and chemotherapy response of EOC patients

From: Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair

  

PFS a

OS a

 

Chemotherapy response b

Variables

Case No. (%)

HR (95% CI)

P Value

HR (95% CI)

P Value

Case No. (%)

OR (95% CI)

P Value

FIGO stage

I–II

18 (29.0)

0.552 (0.184–1.658)

0.290

0.204 (0.027–1.551)

0.125

16 (29.0)

-

-

III–IV

44 (71.0)

1

 

1

 

42 (71.0)

  

Let-7e expression

        

Low

23 (37.1)

2.037 (0.912–4.554)

0.083

3.235 (1.258–8.317)

0.015

21 (37.1)

19.696 (3.477–111.572)

0.001

High

39 (62.9)

1

 

1

 

37 (62.9)

1

 

BRCA1 expression

        

Low

25 (40.3)

-

-

-

-

23 (40.3)

1

0.155

High

37 (59.7)

    

35 (59.7)

5.042 (0.541–47.011)

 

Rad51 expression

        

Low

32 (51.6)

1

0.029

1

0.404

30 (51.6)

1

0.163

High

30 (48.4)

2.519 (1.098–5.779)

 

1.500 (0.579–3.891)

 

28 (48.4)

4.290 (0.553–33.26)

 
  1. EOC epithelial ovarian cancer, HR hazards ratio, CI confidence interval, PFS progression-free survival, OS overall survival, OR odds ratio, FIGO International Federation of Gynecology and Obstetrics
  2. a Multivariate Cox proportional hazards Regression analysis; b Multivariate logistic regression analysis