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Fig. 4 | Journal of Ovarian Research

Fig. 4

From: Suppressing miR-199a-3p by promoter methylation contributes to tumor aggressiveness and cisplatin resistance of ovarian cancer through promoting DDR1 expression

Fig. 4

DDR1 functions as a downstream effector of miR-199a-3p on the migration, invasion, and tumorigenicityof ovarian cancer cells. a Photographs of the scratch wound assay after stable knockdown of DDR1 or treatment with an anti-miRNA inhibitor specific for miR-199a-3p or negative control in SKOV3 cells. b Relative wound closure rates were measured 48 h after indicated treatments for three independent experiments. *P < 0.05. c Photographs of the transwell assay after the same treatments as (a). d The numbers of invasion cells were counted 48 h after indicated treatments for three independent experiments. *P < 0.05. e Representative images of colony formation in SKOV3 cells with the same treatments as (a). f Quantification of colony formation in (e). *P < 0.05

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