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Fig. 5 | Journal of Ovarian Research

Fig. 5

From: Suppressing miR-199a-3p by promoter methylation contributes to tumor aggressiveness and cisplatin resistance of ovarian cancer through promoting DDR1 expression

Fig. 5

Dysregulation of miR-199a-3p/DDR1 pathway confers the cisplatinresistance in ovarian cancer. a-c The viability of SKOV3 cells with knockdown of DDR1 (a), HO-8910 cells with knockdown of DDR1 (b), and SKOV3 cells with stable knockdown of DDR1 or miR-199a-3p inhibitor treatment (c) for 48 h were determined by the CCK-8 assay under different concentrations of cisplatin. d Cleaved PARP and caspase 3 in the SKOV3 cells with stable knockdown of DDR1 or miR-199a-3p inhibitor treatment were detected 48 h after 10 μM cisplatin addition. e Apoptosis levels of the SKOV3 cells with the same treatments as (d) were measured 48 h after 10 μM cisplatin addition. f Analysis of three independent experiments in (e). *P < 0.05

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