A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature

Jia, Nan; Chen, Yan; Tao, Xiang; Ou, Enzhi; Lu, Xin; Feng, Weiwei

doi:10.1186/s13048-017-0334-3

Table 2 Choriocarcinoma of the ovary: a summary of cases

From: A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature

Authors	Age	Reproductive history	β-hCG (mIU/ml)	Surgery	Chemotherapy	Outcome	DNA polymorphic analysis
Gestational choriocacinoma
Lorigan,1996 [24]	41	NS	151,500	TAH,BSO	BEP then EI	NED	Yes
Our case	27	G0	>200,000	ROC	EP-EMA	NED 32 mo	Yes
Non-gestational choriocacinoma
Vance,1985 [5]	9	NI	34	RO	VEP	NED 12 mo	No
Raju,1985 [6]	16	NI	NS	Autopsy	None	DOD	No
Axe,1985 [1]	6	NI	Normal	RO	None	NED 10 yrs	No
Axe,1985 [1]	11	NI	Elevated	RO	MAV	DOD	No
Sengupta, 1987 [7]	11	NI	NS	UO	NS	NS	No
Spingler,1990 [19]	20	Swyer syndrome	NS	Yes,NS	NS	DOD	No
Gribbon,1992 [8]	NS	NI	Elevated	Yes,NS	NS	DOD 4 mo	No
Gribbon,1992 [8]	11	NI	Elevated	Yes,NS	NS	NED 1 yr	No
Brown,1993 [9]	11	NI	NS	USO	NS	NED 32 mo	No
Trigueros,1995 [10]	21	NI	200,000	TAH,BSO	PVB	NED 4 yrs	No
Gungor,1999 [11]	16	NI	20,000	TAH, cytodeduction, omentectomy, appendectomy	EMA-CO	DOD 6 mo	No
Inaba,2000 [12]	12	NI	1,100,000	RSO,LOC, conservative debulking surgery	BEP then EIC	NED 12 mo	No
Goswami, 2001 [13]	18	NI	88,385	LSO,ROC,omental and peritoneal biopsies	MA and oral chlorambucil	NED 5 mo	No
Ozdemir, 2002 [14]	13	NI	91,028	RSO	MAC	NED 9 mo	No
Tsujioka, 2003 [20]	19	NS	110,000	LSO	EMA-CO	NS	Yes
Koo,2006 [21]	33	G0	185,000	TAH,BSO,PLND	MAC	NED 18 mo	Yes
Yamamoto,2007 [22]	19	NS	206,949	LO	EMA,then EA	NED 12 mo	Yes
Kong,2009 [4]	10	NI	NS	LSO,partial omentectomy	PVB	NED 3 mo	No
Exman,2013 [23]	24	G1P0	675,713	TAH,BSO	BEP	NED	Yes
Heo,2014 [15]	12	NI	20,257	LSO	BEP	NED 14 mo	No
Hayashi,2015 [16]	10	NI	6600	RSO	BEP	NED 62 mo	No
Xin,2015 [17]	23	NI	18,000	tumor enucleation, LSO, pelvic peritonectomy, PaLND, omentectomy	BEP	NED 9 mo	No
Wang,2016 [18]	13	NI	Elevated	TAH,LSO,debulking surgery	PVB	DOD 3 mo	No
Wang,2016 [18]	13	NI	NS	LSO	NS	Lost follow-up in 1 yr	No
Uncertain etiology
Jacobs,1982 [33]	30	G1P1	350,000	lumpectomy	MTX	NED 2 yrs	No
Axe,1985 [1]	21	G1P1	Elevated	RO	MAV	NED 8 yrs	No
Axe,1985 [1]	20	NS	Elevated	RO,appendectomy	MTX	NED 16 yrs	No
Axe,1985 [1]	36	G4P2	Elevated	TAH,BSO,appendectomy	MTX	NED 19 yrs	No
Axe,1985 [1]	35	G4P4	Elevated	TAH,BSO,PLND	PBC	NED 9 mo	No
Kim,1990 [35]	16	G0	565,000	TAH,BSO	MAC	DOD during chemo	unknown
Shin,1994 [36]	45	G6P3	132,005	TAH,BSO	MAC	NED 1 yr	unknown
Byeun,1995 [37]	28	G3P2	13,378	RSO	EMA	NED 1 yr	unknown
Balat,2004 [38]	28	NS	13,378	TAH,BSO,PLND	BEP	DOD during chemo	No
Bazot,2004 [39]	38	P0	2,460,000	TAH,BSO	NS	NED 7 yrs	No
Gerson,2005 [25]	33	G5P3	564,000	RSO,TAH,LSO,splenectomy	EMA-CO	NED 12 mo	No
Corakci,2005 [34]	22	G1P1	15,050	TAH,BSO,PLND,PaLND	BEP	NED 25 mo	No
Hirabayashi,2006 [40]	50	G0	704	TAH,RSO,PLND	P(ip) + TC,EP-EMA,P-EMA(ip)	DOD 10 mo	No
Roghaei,2007[41]	47	G5P5, menopause	970	TAH,BSO,PLND	EMA-CO	NED	No
Park,2009 [26]	55	G5P3	64,838	TAH,BSO	BEP	NED 20 mo	No
Mood,2009 [42]	31	G9P1	>1000	RSO	EMA-CE	NED 7 yrs	No
Mood,2009 [42]	32	G3P2	5500	TAH, BSO, debulking surgery and omentectomy	BEP to EMA-CE	NED 5 yrs	No
Gon,2010 [43]	21	G0	279,000	RSO	NS	NS	No
Lv,2011 [2]	48	G1P1	7664	sub-extensive TAH,BSO,PLND,PaLND	BEP	NED 12 mo	No
Choi,2013 [27]	33	G4P2	74,612	LO,ROC	EMA	NED 5 yrs	No
Haruma,2015 [44]	19	G0	373,170	LSO	EMA-CO	NED 10 mo	No
Rao,2015 [45]	26	G1P1	8160	RSO,partial omentectomy, partial splenectomy and right adrenalectomy	BEO	brain metastasis 2 years after primary treatment	No

NS not stated, NI no intercourse, NED no evidence of disease, DOD dead of disease, mo, months, yr. year

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