Plasma levels of MMP-7 and TIMP-1 in laboratory diagnostics and differentiation of selected histological types of epithelial ovarian cancers

Table 4 The diagnostic criteria of MMP-7, TIMP-1 in combination with HE4 and CA 125 in epithelial ovarian cancer patients

Epithelial ovarian cancer	Diagnostic criteria (%)	MMP-7 + HE4	MMP-7 + CA125	TIMP-1 + HE4	TIMP-1 + CA 125	HE4 + CA 125	MMP-7 + HE4 + CA125	TIMP-1 + HE4 + CA 125
Stage I	SE	71	63	54	42	63	75	63
	SP	91	94	91	94	94	89	89
	PPV	74	79	68	71	79	72	68
	NPV	89	87	84	81	87	91	86
Stage II	SE	62	65	62	42	73	81	73
	SP	91	94	91	94	94	89	89
	PPV	73	81	73	73	83	75	73
	NPV	85	87	85	80	90	92	89
Stage III	SE	96	92	88	85	96	100	100
	SP	91	94	91	94	94	89	89
	PPV	81	86	79	85	86	79	79
	NPV	98	97	95	94	98	100	100
Stage IV	SE	92	96	79	83	96	96	96
	SP	91	94	91	94	94	89	89
	PPV	79	85	76	83	85	77	77
	NPV	97	98	92	94	98	98	98
Total group	SE	80	81	71	63	82	88	83
	SP	91	94	91	94	94	89	89
	PPV	93	95	92	94	95	93	92
	NPV	75	74	67	62	77	83	77

ISSN: 1757-2215