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Table 4 The diagnostic criteria of MMP-7, TIMP-1 in combination with HE4 and CA 125 in epithelial ovarian cancer patients

From: Plasma levels of MMP-7 and TIMP-1 in laboratory diagnostics and differentiation of selected histological types of epithelial ovarian cancers

Epithelial ovarian cancer Diagnostic criteria (%) MMP-7 + HE4 MMP-7 + CA125 TIMP-1 + HE4 TIMP-1 + CA 125 HE4 + CA 125 MMP-7 + HE4 + CA125 TIMP-1 + HE4 + CA 125
Stage I SE 71 63 54 42 63 75 63
SP 91 94 91 94 94 89 89
PPV 74 79 68 71 79 72 68
NPV 89 87 84 81 87 91 86
Stage II SE 62 65 62 42 73 81 73
SP 91 94 91 94 94 89 89
PPV 73 81 73 73 83 75 73
NPV 85 87 85 80 90 92 89
Stage III SE 96 92 88 85 96 100 100
SP 91 94 91 94 94 89 89
PPV 81 86 79 85 86 79 79
NPV 98 97 95 94 98 100 100
Stage IV SE 92 96 79 83 96 96 96
SP 91 94 91 94 94 89 89
PPV 79 85 76 83 85 77 77
NPV 97 98 92 94 98 98 98
Total group SE 80 81 71 63 82 88 83
SP 91 94 91 94 94 89 89
PPV 93 95 92 94 95 93 92
NPV 75 74 67 62 77 83 77