Table 7 The diagnostic criteria of the ROC curve for MMP-7, TIMP-1in combination with HE4 and CA125 in epithelial ovarian cancer patients

Stage I

AUC

0.8596^a

0.7981^a

0.7795^a

0.6532^a

0.8474^a

0.8635^a

0.8071^a

SE

0.0571

0.0689

0.0668

0.0730

0.0573

0.0566

0.0646

95% C.I.

0.748–0.972

0.663–0.933

0.648–0.910

0.510–0.796

0.735–0.960

0.752–0.974

0.681–0.934

pAUC = 0.5

<0.001

<0.001

<0.001

0.0359

<0.001

<0.001

<0.001

Stage II

AUC

0.8456^a

0.9284^a

0.8290^a

0.7479^a

0.9331^a

0.9385^a

0.8982^a

SE

0.0521

0.0262

0.0556

0.0722

0.0255

0.0234

0.0401

95% C.I.

0.744–0.948

0.877–0.980

0.720–0.938

0.607–0.889

0.883–0.983

0.893–0.984

0.820–0.977

pAUC = 0.5

<0.001

<0.001

<0.001

0.006

<0.001

<0.001

<0.001

Stage III

AUC

0.9864^a

0.9704^a

0.9657^a

0.9349^a

0.9893^a

0.9935^a

0.9923^a

SE

0.0085

0.0233

0.0225

0.0412

0.0070

0.0052

0.0060

95% C.I.

0.970–1.003

0.925–1.016

0.922–1.010

0.854–1.016

0.976–1.003

0.983–1.004

0.981–1.004

pAUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

Stage IV

AUC

0.9513^a

0.9519^a

0.9673^a

0.9423^a

0.9487^a

0.9788^a

0.9526^a

SE

0.0406

0.0399

0.0155

0.0329

0.0370

0.0119

0.0405

95% C.I.

0.872–1.031

0.874–1.030

0.937–0.998

0.878–1.007

0.876–1.021

0.955–1.002

0.873–1.032

pAUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

Total group

AUC

0.9109^a

0.9137^a

0.8858^a

0.8205^a

0.9309^a

0.9382^a

0.9202^a

SE

0.0237

0.0239

0.0263

0.0332

0.0205

0.0198

0.0222

95% C.I.

0.864–0.957

0.867–0.961

0.834–0.937

0.755–0.885

0.891–0.971

0.899–0.977

0.877–0.964

pAUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001