EOC | The ROC criteria | MMP-7 + HE4 | MMP-7 + CA 125 | TIMP-1 + HE4 | TIMP-1 + CA 125 | HE4 + CA 125 | MMP-7 + HE4 + CA 125 | TIMP-1 + HE4 + CA 125 |
---|---|---|---|---|---|---|---|---|
Stage I | AUC | 0.8596a | 0.7981a | 0.7795a | 0.6532a | 0.8474a | 0.8635a | 0.8071a |
SE | 0.0571 | 0.0689 | 0.0668 | 0.0730 | 0.0573 | 0.0566 | 0.0646 | |
95% C.I. | 0.748–0.972 | 0.663–0.933 | 0.648–0.910 | 0.510–0.796 | 0.735–0.960 | 0.752–0.974 | 0.681–0.934 | |
pAUC = 0.5 | <0.001 | <0.001 | <0.001 | 0.0359 | <0.001 | <0.001 | <0.001 | |
Stage II | AUC | 0.8456a | 0.9284a | 0.8290a | 0.7479a | 0.9331a | 0.9385a | 0.8982a |
SE | 0.0521 | 0.0262 | 0.0556 | 0.0722 | 0.0255 | 0.0234 | 0.0401 | |
95% C.I. | 0.744–0.948 | 0.877–0.980 | 0.720–0.938 | 0.607–0.889 | 0.883–0.983 | 0.893–0.984 | 0.820–0.977 | |
pAUC = 0.5 | <0.001 | <0.001 | <0.001 | 0.006 | <0.001 | <0.001 | <0.001 | |
Stage III | AUC | 0.9864a | 0.9704a | 0.9657a | 0.9349a | 0.9893a | 0.9935a | 0.9923a |
SE | 0.0085 | 0.0233 | 0.0225 | 0.0412 | 0.0070 | 0.0052 | 0.0060 | |
95% C.I. | 0.970–1.003 | 0.925–1.016 | 0.922–1.010 | 0.854–1.016 | 0.976–1.003 | 0.983–1.004 | 0.981–1.004 | |
pAUC = 0.5 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
Stage IV | AUC | 0.9513a | 0.9519a | 0.9673a | 0.9423a | 0.9487a | 0.9788a | 0.9526a |
SE | 0.0406 | 0.0399 | 0.0155 | 0.0329 | 0.0370 | 0.0119 | 0.0405 | |
95% C.I. | 0.872–1.031 | 0.874–1.030 | 0.937–0.998 | 0.878–1.007 | 0.876–1.021 | 0.955–1.002 | 0.873–1.032 | |
pAUC = 0.5 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | |
Total group | AUC | 0.9109a | 0.9137a | 0.8858a | 0.8205a | 0.9309a | 0.9382a | 0.9202a |
SE | 0.0237 | 0.0239 | 0.0263 | 0.0332 | 0.0205 | 0.0198 | 0.0222 | |
95% C.I. | 0.864–0.957 | 0.867–0.961 | 0.834–0.937 | 0.755–0.885 | 0.891–0.971 | 0.899–0.977 | 0.877–0.964 | |
pAUC = 0.5 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 |