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Table 7 The diagnostic criteria of the ROC curve for MMP-7, TIMP-1in combination with HE4 and CA125 in epithelial ovarian cancer patients

From: Plasma levels of MMP-7 and TIMP-1 in laboratory diagnostics and differentiation of selected histological types of epithelial ovarian cancers

EOC The ROC criteria MMP-7 + HE4 MMP-7 + CA 125 TIMP-1 + HE4 TIMP-1 + CA 125 HE4 + CA 125 MMP-7 + HE4 + CA 125 TIMP-1 + HE4 + CA 125
Stage I AUC 0.8596a 0.7981a 0.7795a 0.6532a 0.8474a 0.8635a 0.8071a
SE 0.0571 0.0689 0.0668 0.0730 0.0573 0.0566 0.0646
95% C.I. 0.748–0.972 0.663–0.933 0.648–0.910 0.510–0.796 0.735–0.960 0.752–0.974 0.681–0.934
pAUC = 0.5 <0.001 <0.001 <0.001 0.0359 <0.001 <0.001 <0.001
Stage II AUC 0.8456a 0.9284a 0.8290a 0.7479a 0.9331a 0.9385a 0.8982a
SE 0.0521 0.0262 0.0556 0.0722 0.0255 0.0234 0.0401
95% C.I. 0.744–0.948 0.877–0.980 0.720–0.938 0.607–0.889 0.883–0.983 0.893–0.984 0.820–0.977
pAUC = 0.5 <0.001 <0.001 <0.001 0.006 <0.001 <0.001 <0.001
Stage III AUC 0.9864a 0.9704a 0.9657a 0.9349a 0.9893a 0.9935a 0.9923a
SE 0.0085 0.0233 0.0225 0.0412 0.0070 0.0052 0.0060
95% C.I. 0.970–1.003 0.925–1.016 0.922–1.010 0.854–1.016 0.976–1.003 0.983–1.004 0.981–1.004
pAUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
Stage IV AUC 0.9513a 0.9519a 0.9673a 0.9423a 0.9487a 0.9788a 0.9526a
SE 0.0406 0.0399 0.0155 0.0329 0.0370 0.0119 0.0405
95% C.I. 0.872–1.031 0.874–1.030 0.937–0.998 0.878–1.007 0.876–1.021 0.955–1.002 0.873–1.032
pAUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
Total group AUC 0.9109a 0.9137a 0.8858a 0.8205a 0.9309a 0.9382a 0.9202a
SE 0.0237 0.0239 0.0263 0.0332 0.0205 0.0198 0.0222
95% C.I. 0.864–0.957 0.867–0.961 0.834–0.937 0.755–0.885 0.891–0.971 0.899–0.977 0.877–0.964
pAUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
  1. C.I. – confidence intervals of AUC
  2. aStatistically significant when comparing tested parameters AUC’s with 0.5 AUC
  3. Bold data are statistically significant when p < 0.05