Ovarian preservation in adenocarcinoma of the uterine cervix

Table 2 Univariate and multivariate analyses of risk factors for ovarian metastasis in patients with cervical adenocarcinoma

Parameter	N (%)	Univariate analyses			Multivariate analyses
Total no. of patients enrolled	312	Ovarian metastasis			Odds ratio	p-value
		Yes	No	p-value
Age at surgery
< 60	282 (90.4)	12	270	0.544
≥ 60	30 (9.6)	2	28	0.544
FIGO stage
I	226 (72.4)	5	221	0.002*	2.445	0.243
II	86 (27.6)	9	77	0.002*	2.445	0.243
Tumor diameter (cm)
< 4	221 (70.8)	7	214	0.079
≥ 4	91 (29.2)	7	84	0.079
Differentiation
G1 + G2	191 (61.2)	8	182	0.756
G3	121 (38.8)	6	115	0.756
Tumour morphology
Exophytic	109 (34.9)	8	101	0.075
Endophytic	203 (65.1)	6	197	0.075
Deep stromal invasion
Superficial (<2/3)	210 (67.3)	4	206	0.002*	1.307	0.743
Deep (≥2/3)	102 (32.7)	10	92	0.002*	1.307	0.743
Parametrial invasion
Negative	296 (94.9)	8	288	5.80E-11*	14.125	0.005*
Positive	16 (5.1)	6	10	5.80E-11*	14.125	0.005*
Lymph-vascular space invasion
Negative	197 (63.1)	7	190	0.297
Positive	115 (36.9)	7	108	0.297
Pelvic node status
Negative	227 (72.8)	10	217	0.909
Positive	85 (27.2)	4	81	0.909
Fallopian tube invasion
Negative	302 (96.8)	10	292	3.51E-8*	1.837	0.338
Positive	10 (3.2)	4	6	3.51E-8*	1.837	0.338
Para-aortic node status
Negative	305 (97.8)	13	292	0.205
Positive	7 (2.2)	1	6	0.205
Infiltration to vagina
Yes	58 (18.6)	8	50	1.48E-4*	4.167	0.047*
No	254 (81.4)	6	248	1.48E-4*	4.167	0.047*
Endometrial invasion
Negative	300 (96.2)	11	289	4.65E-4*	3.156	0.213
Positive	12 (3.8)	3	9	4.65E-4*	3.156	0.213
Uterine corpus invasion
Negative	252 (80.8)	5	247	1.20E-5*	5.178	0.019*
Positive	60 (19.2)	9	51	1.20E-5*	5.178	0.019*
Perineural invasion
Negative	271 (86.9)	9	262	0.011*	0.273	0.174
Positive	41 (13.1)	5	36	0.011*	0.273	0.174

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