Fig. 3
From: Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma
SpotStudio Quantification of RNA-CISH in fallopian tube epithelium, STICs, and HGSCs. Using ACD SpotStudio Software, single cell analysis for CISH were done on all 7 matched normal, STIC, and HGSC samples. STICs and HGSC showed a higher percentage of cells overexpressing ADRM1 mRNA as compared to fallopian tube epithelium. Distribution of cells containing higher number of ADRM1 mRNA spots increases FT progresses to STIC and carcinoma. Collectively, STIC and HGSC exhibited significantly different levels as compared to normal (P = 0.009, P = 0.003, paired T-test). One representative case (Patient A) is presented, and the remainder (Patients B-G) are presented in Additional file 4: Figure S4