Skip to main content
Fig. 1 | Journal of Ovarian Research

Fig. 1

From: Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer

Fig. 1

The effect of CTHRC1 on SKOV3 cells migration, invasion and adhesion in vitro. a The knockdown and overexpression of CTHRC1 in SKOV3 cells using CTHRC1-specific shRNA and Lenti-CTHRC1, respectively. b Decreased cellular migration in SKOV3-shCTHRC1 cells and elevated cellular migration in SKOV3-CTHRC1 cells were confirmed by wound healing assays. c Transwell migration and invasion assays showed that SKOV3 cells migratory and invasive capacity was impaired by down-regulation of CTHRC1 and enhanced by the up-regulation of CTHRC1. d Overexpressed CTHRC1 elevated SKOV3 cells adhesion to vitronectin and the knockdown of CTHRC1 reduced SKOV3 cells adhesion to vitronectin (*P < 0.05, **P < 0.01)

Back to article page

Journal of Ovarian Research

ISSN: 1757-2215

Contact us