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Table 1 Mean ± SEM of body weight, glucose level, body mass index, body mass gain, ovarian diameter, abdominal and thoracic circumference in control, PCOS, metformin, GAB 1 (100 mg/kg) and GABA 2 (500 mg/kg) treated groups before and after 36 days of experiment

From: Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats

Parameters

Control

PCOS

Metformin

GABA1

GABA2

Initial Body Weight (gm)

156 ± 01.37

156 ± 05.38

157 ± 07.57

150 ± 05.79

157 ± 04.22

Final Body Weight (gm)

181 ± 04.11

260 ± 02.81***

203 ± 03.29+

210 ± 04.57**++

222.2 ± 02.15**++

Initial Glucose (mg/dL)

117.20 ± 01.93

103.20 ± 02.81

122.41 ± 03.29

113.00 ± 04.57

120.40 ± 02.15

Final Glucose (mg/dL)

120.22 ± 03.21

166.46 ± 20.00***

135.21 ± 01.91++

129.00 ± 05.08+

138.40 ± 06.20+

Body mass Index (g/cm2)

0.49 ± 0.01

0.54 ± 0.02

0.47 ± 0.01

0.72 ± 0.03

0.69 ± 0.04

Body mass gain (g/kg)

4.34 ± 0.94

27.76 ± 8.61

16.21 ± 5.04

29.66 ± 6.47

15.17 ± 7.21

Right Ovary diameter (mm)

4.80 ± 00.37

5.10 ± 01.04

4.60 ± 00.25

6.10 ± 00.96

5.80 ± 00.12

Left Ovary diameter (mm)

5.00 ± 0.44

5.60 ± 0.24

5.20 ± 0.20

6.00 ± 0.15

5.70 ± 0.20

Abdominal Circumference (cm)

1.06 ± 0.09

1.05 ± 0.31

1.06 ± 0.51

1.04 ± 0.44

1.09 ± 0.34

Thoracic circumference (cm)

1.06 ± 0.23

1.05 ± 0.10

1.06 ± 0.18

1.16 ± 0.29

1.22 ± 0.24

  1. Values are expressed as Mean ± SEM
  2. *, **, *** indicate significance from the control group at P < 0.001, 0. 01 and 0.05 probability level
  3. +, ++, +++ indicate significance from the PCOS group at P < 0.001, 0. 01 and 0.05 probability level