Skip to main content

Table 2 Mean ± SEM of total protein, CAT, SOD, POD, GST, GSR, GSH, T-BARS, ROS, cholesterol, triglycerides, HDL, testosterone, progesterone and estradiol concentrations in control, PCOS, metformin, GAB 1 (100 mg/kg) and GABA 2 (500 mg/kg) treated female rats after 34 days of experiment

From: Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats

Parameters

Control

PCOS

Metformin

GABA1

GABA2

Total Protein (mg/g)

2.55 ± 0.23

3.09 ± 0.41

2.77 ± 0.26

2.04 ± 0.05

2.65 ± 0.26

CAT (u/mg)

29.44 ± 2.60

23.41 ± 4.06**

22.63 ± 2.35+

17.05 ± 2.28*

26.94 ± 2.28+

SOD (u/mg)

1.21 ± 0.24

0.99 ± 0.13**

1.90 ± 0.21+++

1.48 ± 0.11+

2.63 ± 0.37*+++

POD (nmole)

0.09 ± 0.16

0.04 ± 0.07*

0.47 ± 0.02+++

0.12 ± 0.09

0.18 ± 0.38++

GST (u/mol/mg)

61.14 ± 11.39

65.82 ± 03.13

55.48 ± 08.27

72.95 ± 17.41

59.31 ± 23.72

GSR (u/mol/mg)

174.36 ± 8.90

29.23 ± 13.30**

162.38 ± 16.60+++

97.66 ± 12.94++

161.09 ± 12.89+++

GSR-PX (u/mol/mg)

24.86 ± 02.97

10.71 ± 04.41

54.30 ± 05.55**+++

48.03 ± 08.81*+++

22.57 ± 03.04

GSH (u/mol/mg)

405.74 ± 36.39

558.79 ± 95.65

405.23 ± 27.63

359.62 ± 06.16

495.53 ± 50.12

T-BARS (nmol/mg)

206.46 ± 33.81

436.70 ± 63.74**

268.63 ± 56.98++

293.39 ± 24.38

245.63 ± 73.20+

ROS (u/min)

39.47 ± 13.63

79.19 ± 11.20*

38.14 ± 03.53+

18.78 ± 11.51+++

12.18 ± 08.60+++

Cholesterol (mg/dL)

215.60 ± 3.43

231.10 ± 4.27*

211.30 ± 6.81

222.21 ± 2.53+

210.10 ± 3.34++

Triglycerides (mg/dL)

185.11 ± 4.23

213.10 ± 5.16**

197.40 ± 5.82

204.20 ± 5.93

190.12 ± 6.32+

HDL (mg/dL)

160.70 ± 4.17

144.41 ± 3.63

153.21 ± 1.80

156.43 ± 5.52

165.34 ± 4.24+

Testosterone (ng/ml)

1.24 ± 0.14

2.07 ± 0.14**

1.24 ± 0.17++

1.50 ± 0.20

1.35 ± 0.10++

Progesterone (ng/ml)

6.96 ± 0.10

6.70 ± 0.15

6.82 ± 0.07

6.63 ± 0.11

6.70 ± 0.21

Estradiol (pg/ml)

4.89 ± 0.14

2.79 ± 0.18*

4.40 ± 0.17+

2.36 ± 0.24

4.46 ± 0.46++

  1. Values are expressed as Mean ± SEM
  2. *, **, *** indicate significance from the control group at P < 0.001, 0. 01 and 0.05 probability level
  3. +, ++, +++ indicate significance from the PCOS group at P < 0.001, 0. 01 and 0.05 probability level