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Table 2 Mean ± SEM of total protein, CAT, SOD, POD, GST, GSR, GSH, T-BARS, ROS, cholesterol, triglycerides, HDL, testosterone, progesterone and estradiol concentrations in control, PCOS, metformin, GAB 1 (100 mg/kg) and GABA 2 (500 mg/kg) treated female rats after 34 days of experiment

From: Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats

Parameters Control PCOS Metformin GABA1 GABA2
Total Protein (mg/g) 2.55 ± 0.23 3.09 ± 0.41 2.77 ± 0.26 2.04 ± 0.05 2.65 ± 0.26
CAT (u/mg) 29.44 ± 2.60 23.41 ± 4.06** 22.63 ± 2.35+ 17.05 ± 2.28* 26.94 ± 2.28+
SOD (u/mg) 1.21 ± 0.24 0.99 ± 0.13** 1.90 ± 0.21+++ 1.48 ± 0.11+ 2.63 ± 0.37*+++
POD (nmole) 0.09 ± 0.16 0.04 ± 0.07* 0.47 ± 0.02+++ 0.12 ± 0.09 0.18 ± 0.38++
GST (u/mol/mg) 61.14 ± 11.39 65.82 ± 03.13 55.48 ± 08.27 72.95 ± 17.41 59.31 ± 23.72
GSR (u/mol/mg) 174.36 ± 8.90 29.23 ± 13.30** 162.38 ± 16.60+++ 97.66 ± 12.94++ 161.09 ± 12.89+++
GSR-PX (u/mol/mg) 24.86 ± 02.97 10.71 ± 04.41 54.30 ± 05.55**+++ 48.03 ± 08.81*+++ 22.57 ± 03.04
GSH (u/mol/mg) 405.74 ± 36.39 558.79 ± 95.65 405.23 ± 27.63 359.62 ± 06.16 495.53 ± 50.12
T-BARS (nmol/mg) 206.46 ± 33.81 436.70 ± 63.74** 268.63 ± 56.98++ 293.39 ± 24.38 245.63 ± 73.20+
ROS (u/min) 39.47 ± 13.63 79.19 ± 11.20* 38.14 ± 03.53+ 18.78 ± 11.51+++ 12.18 ± 08.60+++
Cholesterol (mg/dL) 215.60 ± 3.43 231.10 ± 4.27* 211.30 ± 6.81 222.21 ± 2.53+ 210.10 ± 3.34++
Triglycerides (mg/dL) 185.11 ± 4.23 213.10 ± 5.16** 197.40 ± 5.82 204.20 ± 5.93 190.12 ± 6.32+
HDL (mg/dL) 160.70 ± 4.17 144.41 ± 3.63 153.21 ± 1.80 156.43 ± 5.52 165.34 ± 4.24+
Testosterone (ng/ml) 1.24 ± 0.14 2.07 ± 0.14** 1.24 ± 0.17++ 1.50 ± 0.20 1.35 ± 0.10++
Progesterone (ng/ml) 6.96 ± 0.10 6.70 ± 0.15 6.82 ± 0.07 6.63 ± 0.11 6.70 ± 0.21
Estradiol (pg/ml) 4.89 ± 0.14 2.79 ± 0.18* 4.40 ± 0.17+ 2.36 ± 0.24 4.46 ± 0.46++
  1. Values are expressed as Mean ± SEM
  2. *, **, *** indicate significance from the control group at P < 0.001, 0. 01 and 0.05 probability level
  3. +, ++, +++ indicate significance from the PCOS group at P < 0.001, 0. 01 and 0.05 probability level