Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats

Table 3 Mean ± SEM number of ovarian follicles in control, PCOS, metformin, GAB 1 (100 mg/kg) and GABA 2 (500 mg/kg) after 34 days of experiment

Developing follicles (μm)	CONTROL	PCOS	METFORMIN	GABA 1	GABA 2
D 20–60	8.66 ± 0.55	9.00 ± 0.73	7.16 ± 0.70	9.66 ± 0.55	8.50 ± 0.50
D 60–100	7.60 ± 0.50	7.60 ± 0.92	7.20 ± 0.66	5.20 ± 0.91	5.20 ± 0.58
D 100–200	7.00 ± 0.70	3.00 ± 0.54*	8.20 ± 1.06	3.80 ± 0.80	4.80 ± 0.37
D 200–400	8.00 ± 0.70	4.60 ± 0.74	6.60 ± 1.07	4.80 ± 0.73	4.20 ± 0.73
D 400–600	2.20 ± 0.37	0.80 ± 0.58	1.00 ± 0.44	0.80 ± 0.37	0.60 ± 0.24
>600	3.20 ± 0.37	0.80 ± 0.58	0.60 ± 0.24	0.40 ± 0.24	1.20 ± 0.37
Cystic Follicle	0.00 ± 0.00	9.17 ± 0.70 **	5.16 ± 0.30++	6.16 ± 0.47++	7.33 ± 0.42 +
Corpus Luteum	8.80 ± 0.37	2.40 ± 0.24 ***	4.20 ± 0.58 +	2.40 ± 0.50 ++	4.40 ± 0.24 ⁺⁺
Atretic Follicle	4.00 ± 0.25	3.50 ± 0.34 ^**+++	2.83 ± 0.47	2.66 ± 0.33	2.83 ± 0.40 +

Values are expressed as Mean ± SEM
*, **, *** indicate significance from the control group at P < 0.001, 0.01 and 0.05 probability level
+, ++, +++ indicate significance from the PCOS group at P < 0.05, P < 0.01 and P < 0.001 probability level

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