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Table 3 Mean ± SEM number of ovarian follicles in control, PCOS, metformin, GAB 1 (100 mg/kg) and GABA 2 (500 mg/kg) after 34 days of experiment

From: Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats

Developing follicles (μm) CONTROL PCOS METFORMIN GABA 1 GABA 2
D 20–60 8.66 ± 0.55 9.00 ± 0.73 7.16 ± 0.70 9.66 ± 0.55 8.50 ± 0.50
D 60–100 7.60 ± 0.50 7.60 ± 0.92 7.20 ± 0.66 5.20 ± 0.91 5.20 ± 0.58
D 100–200 7.00 ± 0.70 3.00 ± 0.54* 8.20 ± 1.06 3.80 ± 0.80 4.80 ± 0.37
D 200–400 8.00 ± 0.70 4.60 ± 0.74 6.60 ± 1.07 4.80 ± 0.73 4.20 ± 0.73
D 400–600 2.20 ± 0.37 0.80 ± 0.58 1.00 ± 0.44 0.80 ± 0.37 0.60 ± 0.24
>600 3.20 ± 0.37 0.80 ± 0.58 0.60 ± 0.24 0.40 ± 0.24 1.20 ± 0.37
Cystic Follicle 0.00 ± 0.00 9.17 ± 0.70 ** 5.16 ± 0.30++ 6.16 ± 0.47++ 7.33 ± 0.42 +
Corpus Luteum 8.80 ± 0.37 2.40 ± 0.24 *** 4.20 ± 0.58 + 2.40 ± 0.50 ++ 4.40 ± 0.24 ++
Atretic Follicle 4.00 ± 0.25 3.50 ± 0.34 **+++ 2.83 ± 0.47 2.66 ± 0.33 2.83 ± 0.40 +
  1. Values are expressed as Mean ± SEM
  2. *, **, *** indicate significance from the control group at P < 0.001, 0.01 and 0.05 probability level
  3. +, ++, +++ indicate significance from the PCOS group at P < 0.05, P < 0.01 and P < 0.001 probability level