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Table 3 Clinical response of individual patients after monotherapy, monotherapy plus Avastin or combination therapy

From: Prediction of clinical response to drugs in ovarian cancer using the chemotherapy resistance test (CTR-test)

Non-Responder Responder
Patient Substance CTR-Test Patient Substance CTR-Test
Monotherapy
 1 Carbo ER 13 Pac SR
 2 Caelyx SR 14 Carbo SR
 3 Topo SR 15 Topo SR
 4 Carbo SR 16 Pac MR
 5 Topo MR    
 6 Topo MR    
 7 Caelyx MR    
 8 Caelyx ER    
 9 Caelyx MR    
 10 Topo SR    
 11 Topo ER    
 12 Topo ER    
(Mono)
 1 Caelyx + Avastin SR 2 Caelyx + Avastin SR
    3 Topo + Avastin MR
Combination Chemotherapy
Patient Substance CTR-Test Scorea Patient Substance CTR-Test Scorea
 1 Carbo/Pac ER/ER 0 9 Carbo/Caelyx SR/SR 4
 2 Carbo/Caelyx MR/ER 1 10 Carbo/Gem SR/SR 4
 3 Carbo/Gem ER/ER 0 11 Carbo/Pac SR/SR 4
 4 Carbo/Pac SR/SR 4 12 Carbo/Caelyx SR/ER 2
 5 Carbo/Gem ER/ER 0 13 Carbo/Caelyx SR/ER 2
 6 Carbo/Pac ER/SR 2 14 Carbo/Caelyx SR/MR 3
 7 Carbo/Caelyx MR/ER 1 15 Carbo/Caelyx SR/SR 4
 8 Carbo/Pac MR/ER 1 16 Carbo/Pac MR/ER 1
     17 Carbo/Pac SR/MR 3
     18 Carbo/Caelyx MR/SR 3
     19 Carbo/Caelyx SR/SR 4
     20 Carbo/Pac SR/MR 3
     21 Carbo/Caelyx SR/MR 3
     22 Carbo/Gem ER/SR 2
     23 Carbo/Pac SR/SR 4
     24 Carbo/Caelyx MR/MR 2
     25 Carbo/Pac SR/MR 3
     26 Carbo/Caelyx MR/MR 2
     27 Carbo/Caelyx SR/MR 3
     28 Carbo/Pac SR/MR 3
     29 Carbo/Pac SR/MR 3
     30 Carbo/Pac SR/SR 4
     31 Carbo/Pac SR/SR 4
     32 Carbo/Pac ER/SR 2
     33 Carbo/Caelyx SR/SR 4
  1. The applied chemotherapeutics and the corresponding results of the CTR-Test for individual patients are listed. Patients were classified as non-responders and responders
  2. Abbreviations: Carbo Carboplatin, Gem Gemcitabine, Pac Paclitaxel, Topo Topotecan, ER extreme resistance, MR medium resistance, SR slight resistance, Caelyx doxorubicin-hydrochloride in a pegylated liposomal formulation
  3. aFor combination therapy the two single drugs were measured and scores were determined according to the resistance categories: ER = 0; MR = 1; SR = 2. The scores obtained are 4 = SR/SR; 3 = MR/SR, SR/MR; 2 = ER/SR, SR/ER, MR/MR; 1 = ER/MR, MR/ER; 0 = ER/ER