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Table 3 Clinical response of individual patients after monotherapy, monotherapy plus Avastin or combination therapy

From: Prediction of clinical response to drugs in ovarian cancer using the chemotherapy resistance test (CTR-test)

Non-Responder

Responder

Patient

Substance

CTR-Test

Patient

Substance

CTR-Test

Monotherapy

 1

Carbo

ER

13

Pac

SR

 2

Caelyx

SR

14

Carbo

SR

 3

Topo

SR

15

Topo

SR

 4

Carbo

SR

16

Pac

MR

 5

Topo

MR

   

 6

Topo

MR

   

 7

Caelyx

MR

   

 8

Caelyx

ER

   

 9

Caelyx

MR

   

 10

Topo

SR

   

 11

Topo

ER

   

 12

Topo

ER

   

(Mono)

 1

Caelyx + Avastin

SR

2

Caelyx + Avastin

SR

   

3

Topo + Avastin

MR

Combination Chemotherapy

Patient

Substance

CTR-Test

Scorea

Patient

Substance

CTR-Test

Scorea

 1

Carbo/Pac

ER/ER

0

9

Carbo/Caelyx

SR/SR

4

 2

Carbo/Caelyx

MR/ER

1

10

Carbo/Gem

SR/SR

4

 3

Carbo/Gem

ER/ER

0

11

Carbo/Pac

SR/SR

4

 4

Carbo/Pac

SR/SR

4

12

Carbo/Caelyx

SR/ER

2

 5

Carbo/Gem

ER/ER

0

13

Carbo/Caelyx

SR/ER

2

 6

Carbo/Pac

ER/SR

2

14

Carbo/Caelyx

SR/MR

3

 7

Carbo/Caelyx

MR/ER

1

15

Carbo/Caelyx

SR/SR

4

 8

Carbo/Pac

MR/ER

1

16

Carbo/Pac

MR/ER

1

    

17

Carbo/Pac

SR/MR

3

    

18

Carbo/Caelyx

MR/SR

3

    

19

Carbo/Caelyx

SR/SR

4

    

20

Carbo/Pac

SR/MR

3

    

21

Carbo/Caelyx

SR/MR

3

    

22

Carbo/Gem

ER/SR

2

    

23

Carbo/Pac

SR/SR

4

    

24

Carbo/Caelyx

MR/MR

2

    

25

Carbo/Pac

SR/MR

3

    

26

Carbo/Caelyx

MR/MR

2

    

27

Carbo/Caelyx

SR/MR

3

    

28

Carbo/Pac

SR/MR

3

    

29

Carbo/Pac

SR/MR

3

    

30

Carbo/Pac

SR/SR

4

    

31

Carbo/Pac

SR/SR

4

    

32

Carbo/Pac

ER/SR

2

    

33

Carbo/Caelyx

SR/SR

4

  1. The applied chemotherapeutics and the corresponding results of the CTR-Test for individual patients are listed. Patients were classified as non-responders and responders
  2. Abbreviations: Carbo Carboplatin, Gem Gemcitabine, Pac Paclitaxel, Topo Topotecan, ER extreme resistance, MR medium resistance, SR slight resistance, Caelyx doxorubicin-hydrochloride in a pegylated liposomal formulation
  3. aFor combination therapy the two single drugs were measured and scores were determined according to the resistance categories: ER = 0; MR = 1; SR = 2. The scores obtained are 4 = SR/SR; 3 = MR/SR, SR/MR; 2 = ER/SR, SR/ER, MR/MR; 1 = ER/MR, MR/ER; 0 = ER/ER