Table 1 Concentrations of TIMP3, MMP3, HE4 and CA125 in blood serum, depending on the histopathologic diagnosis of patients
variable | ovarian cancer | ovarian simple cysts | p | ||||
n | mean range | median 95% CI | n | mean range | median 95% CI | ||
age | 44 | 61.4 (49–78) | 62.2 (52–76.4) | 30 | 58 (42–66) | 58.6 (44–62.5) | NS |
TIMP3 [pg/ml] | 44 | 138 (67–198) | 143 (151–188) | 30 | 285 (148–368) | 291 (298–355) | p = 0.001 |
MMP3 [pg/ml] | 44 | 20836 (16211–28994) | 21022 (16750–26877) | 30 | 14657 (10987–21003) | 15221 (11234–15001) | p = 0.0002 |
HE4 [pmol/l] | 44 | 423 (238–698) | 451.6 (250.2–644) | 30 | 54.6 (41–79.6) | 57 (44–75.2) | p = 0.0004 |
CA125 [U/ml] | 44 | 728 (432–1254) | 790.3 (478.1–1187) | 30 | 19.3 (11.3–37.1) | 25 (14.3–35.2) | p = 0.0001 |
variable | ovarian cancer | endometrial ovarian cysts | p | ||||
n | mean range | median 95% CI | n | mean range | median 95% CI | ||
age | 44 | 61.4 (49–78) | 62.2 (52–76.4) | 30 | 48.9 (40.2–64.3) | 48 (46–64) | NS |
TIMP3 [pg/ml] | 44 | 138 (67–198) | 143 (151–188) | 30 | 223 (143–276) | 241 (256–270) | p = 0.003 |
MMP3 [pg/ml] | 44 | 20836 (16211–28994) | 21022 (16750–26877) | 30 | 14111 (10198–19872) | 15231 (11263–18862) | p = 0.004 |
HE4 [pmol/l] | 44 | 423 (238–698) | 451.6 (250.2–644) | 30 | 61.3 (34–87) | 64 (37.6–82.4) | p = 0.002 |
CA125 [U/ml] | 44 | 728 (432–1254) | 790.3 (478.1–1187) | 30 | 45.2 (23–98) | 47 (24.5–86.2) | p = 0.001 |