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Table 3 Cox regression analyses of progression free survival and overall survival of classic prognostic factor, MMP3 and TIMP3

From: Suitability assessment of baseline concentration of MMP3, TIMP3, HE4 and CA125 in the serum of patients with ovarian cancer

  Univariate analysis (Cox regression model)
PFS OS
HR 95% CI p-value HR 95% CI p-value
Age 1.01 0.78–1.08 0.061 1.091 1.01–1.09 0.002
Stage I, II vs. III, IV 3.89 1.73–8.21 0.0001 4.44 1.36–7.98 0.0004
Grade 1 vs. 3 1.09 0.72–2.61 0.1 1.18 0.55–2.26 0.073
Optimal debulking vs. suboptimal debulking 2.07 1.12–4.41 0.0141 1.24 0.57–2.9 0.068
MMP3 - median 1.22 1.01–3.21 0.00023 1.48 0.95–3.73 0.0064
TIMP3 - median 1.68 0.99–4.21 0.00037 1.89 1.21–4.22 0.0073
  Multivariate analysis (Cox regression model)
PFS OS
HR 95% CI p-value HR 95% CI p-value
MMP3 – median 1.14 0.39–1.67 0.0017 1.04 0.78–1,61 0.0001
MMP3–75 percentile 1.03 0.54–2.31 0.08 0.84 0.29–2.76 0.0548
MMP3–95 percentile 1.19 0.15–0.81 0.42 1.04 0.2–0.76 0.007
TIMP3 - median 1.49 0.23–2.68 0.032 1.6 0.43–1.98 0.003
TIMP3–75 percentile 1.01 0.63–3.02 0.005 1.12 0.82–2.21 0.005
TIMP3–95 percentile 1.33 0.88–3.56 0.004 1.092 0.76–3.11 0.03