Table 3 Cox regression analyses of progression free survival and overall survival of classic prognostic factor, MMP3 and TIMP3

HR

95% CI

p-value

HR

95% CI

p-value

Age

1.01

0.78–1.08

0.061

1.091

1.01–1.09

0.002

Stage I, II vs. III, IV

3.89

1.73–8.21

0.0001

4.44

1.36–7.98

0.0004

Grade 1 vs. 3

1.09

0.72–2.61

0.1

1.18

0.55–2.26

0.073

Optimal debulking vs. suboptimal debulking

2.07

1.12–4.41

0.0141

1.24

0.57–2.9

0.068

MMP3 - median

1.22

1.01–3.21

0.00023

1.48

0.95–3.73

0.0064

TIMP3 - median

1.68

0.99–4.21

0.00037

1.89

1.21–4.22

0.0073

HR

95% CI

p-value

HR

95% CI

p-value

MMP3 – median

1.14

0.39–1.67

0.0017

1.04

0.78–1,61

0.0001

MMP3–75 percentile

1.03

0.54–2.31

0.08

0.84

0.29–2.76

0.0548

MMP3–95 percentile

1.19

0.15–0.81

0.42

1.04

0.2–0.76

0.007

TIMP3 - median

1.49

0.23–2.68

0.032

1.6

0.43–1.98

0.003

TIMP3–75 percentile

1.01

0.63–3.02

0.005

1.12

0.82–2.21

0.005

TIMP3–95 percentile

1.33

0.88–3.56

0.004

1.092

0.76–3.11

0.03