Fig. 3

Images of the most common OC after 180 days of DMBA induction. The left ovaries of animals in the OC group presented a solid mass with necrotic spots (a and c). The left ovary of an animal treated with P-MAPA displayed a large cyst with serous secretions (b and f). CIS-treated (c and g) and P-MAPA+CIS-treated (d and h) animals presented a soft and mobile OC tissue with few adhesions. Right ovaries were sham-operated controls. i Abdominal cavity was opened to show an untreated neoplasm (white arrowhead). j A number of peritoneal implants (yellow arrowhead) with complex abdominal adhesions appeared in some untreated animals. k Left OC (black arrowhead) of a treated animal after the combination of P-MAPA and CIS. l Kaplan-Meier Curve showing animal survival rates (%) following the treatments (log-rank test p = 0.031; * shows significant differences from the OC group)