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Fig. 2 | Journal of Ovarian Research

Fig. 2

From: Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death

Fig. 2

ST6Gal-I overexpression attenuates serine/threonine kinase activity. Bar and volcano plots of kinases with altered STK activity in OV4 OE vs. EV cells. a. Bar plot of serine/threonine kinases identified with the BioNavigator UpKin STK PamApp v14.0 (PamGene) scored as increased (rightward) or decreased (leftward) in OE relative to EV. Length of bar indicates extent of change (KSTAT; Kinase Statistic) and color of bar indicates specificity of each kinase to the predicted phosphosites used to measure its respective activity. b. In the volcano plot, kinases are similarly scored as increased or decreased (y axis) in OE relative to EV, colored by specificity. A combined KSTAT + specificity score (x axis) is denoted, with text size indicating the number of seed peptides used to identify that kinase

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Journal of Ovarian Research

ISSN: 1757-2215

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