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Table 3 Associations between COX expression levels and ovarian cancer survival, the Vanderbilt TROC

From: Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors

  Disease-free survival (DFS), hazard ratio (95% CI), P-value Overall survival (OS), hazard ratio (95% CI), P-value
IHC1 H-Score2 QPCR3 IHC1 H-Score2 QPCR3
COX-1 / PTGS1
 N cases / eventsa 47 / 15 vs 71 / 42 60 / 26 vs 58 / 31 15 / 12 vs 17 / 13 77 / 43 vs 113 / 77 95 / 57 vs 95 / 63 24 / 19 vs 25 / 18
 Unadjusted 2.34 (1.30–4.24) 0.005 1.49 (0.88–2.50) 0.138 1.77 (0.79–3.98) 0.168 1.13 (0.78–1.65) 0.515 1.09 (0.76–1.56) 0.647 1.17 (0.61–2.23) 0.641
 Adjustedb 1.58 (0.85–2.94) 0.148 1.44 (0.85–2.43) 0.180 4.12 (1.51–11.26) 0.006 0.79 (0.54–1.16) 0.227 0.97 (0.68–1.40) 0.882 2.02 (0.96–4.22) 0.063
 Adjustedc 1.55 (0.81–2.98) 0.187 1.30 (0.75–2.34) 0.356 6.37 (1.84–22.01) 0.003 0.87 (0.59–1.30) 0.495 1.14 (0.78–1.65) 0.504 2.26 (1.04–4.91) 0.039
COX-2 / PTGS2
 N cases / events 50 / 33 vs 68 / 24 46 / 29 vs 72 / 28 10 / 10 vs 14 / 9 103 / 80 vs 87 / 40 95 / 72 vs 95 / 48 18 / 16 vs 18 / 11
 Unadjusted 0.51 (0.30–0.87) 0.013 0.61 (0.36–1.02) 0.061 0.51 (0.20–1.29) 0.154 0.52 (0.36–0.77) < 0.001 0.57 (0.39–0.82) 0.002 0.59 (0.27–1.27) 0.173
 Adjustedb 1.53 (0.85–2.76) 0.160 1.93 (1.08–3.46) 0.028 0.86 (0.30–2.45) 0.772 0.85 (0.57–1.27) 0.420 0.89 (0.61–1.31) 0.559 0.77 (0.35–1.71) 0.519
 Adjustedc 1.54 (0.84–2.80) 0.161 1.92 (1.06–3.49) 0.033 0.87 (0.31–2.47) 0.798 1.05 (0.69–1.59) 0.818 1.05 (0.71–1.56) 0.802 1.40 (0.56–3.51) 0.477
  1. 1COX protein measured by immunohistochemistry: moderate & strong vs weak
  2. 2COX protein measured by H-Score: dichotomized at median
  3. 3COX gene expression measured by quantitative real-time PCR: dichotomized at median
  4. aN cases / N events, reference vs high COX
  5. bAdjusted for age at diagnosis (continuous), stage (early, late), and tumor type (I, II)
  6. cAdditionally adjusted for debulking (optimal, suboptimal, missing) and platinum sensitivity (sensitive, resistant, missing) Bold values denote signficant associations; column percentages may not sum to 100% due to rounding error