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Table 4 Associations between COX H-score and ovarian cancer survival by tumor type, the Vanderbilt TROC

From: Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors

 

Disease-free survival

Overall survival

HR (95% CI), P-value

P-interaction

HR (95% CI), P-value

P-interaction

COX-1 / PTGS1

 Among Type I Cases (N = 65)

  N cases / eventsa

28 / 3 vs 21 / 5

 

39 / 14 vs 26 / 8

 

  Unadjusted

2.20 (0.52–9.20)

0.282

0.537

0.71 (0.29–1.70)

0.435

0.210

  Adjustedb

2.88 (0.55–15.04)

0.209

0.56 (0.23–1.38)

0.210

 Among Type II Cases (N = 125)

  N cases / eventsa

32 / 23 vs 37 / 26

 

56 / 43 vs 69 / 55

 

  Unadjusted

1.32 (0.75–2.31)

0.339

 

1.10 (0.74–1.64)

0.636

 

  Adjustedb

1.34 (0.76–2.37)

0.313

 

1.07 (0.72–1.60)

0.740

 

COX-2 / PTGS2

 Among Type I Cases (N = 65)

  N cases / eventsa

10 / 2 vs 39 / 6

 

19 / 11 vs 46 / 11

 

  Unadjusted

0.90 (0.18–4.52)

0.899

0.181

0.38 (0.16–0.88)

0.023

0.051

  Adjustedb

0.51 (0.08–3.40)

0.490

0.49 (0.20–1.15)

0.102

 Among Type II Cases (N = 125)

  N cases / eventsa

36 / 27 vs 33 / 22

 

76 / 61 vs 49 / 37

 

  Unadjusted

1.07 (0.60–1.88)

0.829

 

0.84 (0.56–1.27)

0.413

 

  Adjustedb

1.93 (1.06–3.53)

0.033

 

1.08 (0.71–1.63)

0.723

 
  1. aN cases / N events, reference vs high COX, measured by H-score, dichotomized at the median
  2. bAdjusted for age at diagnosis (continuous) and stage (early, late) Bold values denote signficant associations; column percentages may not sum to 100% due to rounding error
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Journal of Ovarian Research

ISSN: 1757-2215

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