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Table 2 Univariate and multivariate analyses for disease-free survival in women with ovarian non-serous carcinoma

From: Does the primary route of spread have a prognostic significance in stage III non-serous epithelial ovarian cancer?

 

DFSa

Eventsb

Univariate

Multivariate

p

HR

CI 95%

p

Age, y

  ≤ 53

51.9%

44/87 (50.6%)

    

  > 53

26.7%

61/92 (66.3%)

0.025

   

Menopausal Status

 Premenopausal

56.1%

32/70 (45.7%)

0.003

   

 Postmenopausal

27.7%

73/109 (66.9%)

    

Histologic type

 Clear

29.3%

31/48 (64.6%)

0.310

   

 Müsinöz

48.3%

27/47 (53.8%)

    

 Endometrioid

41.8%

28/52 (53.8%)

    

 Mixt

33.6%

19/32 (59.3%)

    

Route of Spread

 Intraperitoneal

37.6%

43/72 (59.7%)

0.002

   

 Retroperitoneal

66.4%

14/35 (40%)

    

 Intra+Retroperitoneal

25.5%

48/72 (66.6%)

    

Peritoneal cytology

 Positive

38.1%

37/61 (60.6%)

0.717

   

 Negative

40.8%

68/118 (57.6%)

    

Bilateralty

 Unilateral

49.4%

49/97 (50.5%)

0.010

   

 Bilateral

26.8%

56/82 (68.2%)

    

Tumor size(cm)

  < 10

53.4%

21/45 (46.6%)

0.321

   

  ≥ 10

63.3%

16/48 (33.3%)

    

CA-125(IU/ml)

  < 250

38.4%

55/88 (31.4%)

0.720

   

  ≥ 250

39%

47/84 (44.8%)

    

Ascites

 Yes

40.6%

41/79 (51.9%)

0.131

   

 No

39%

64/100 (64%)

    

LN involvement

 Yes

39.9%

62/107 (57.9%)

0.761

   

 No

37.6%

43/72 (59.7%)

    

Omental involvement

 Yes

26.7%

73/106 (68.8%)

< 0.001

   

 No

57.5%

31/71 (43.6%)

    

Grade

 Grade 1-2

63%

26/64 (40.6%)

< 0.001

2.3

1.421-3.929

0.001

 Grade 3

24.4%

48/67 (71.6%)

    

CRS

 Maximal

83.1%

9/51 (17.6%)

< 0.001

5.3

2.374-12.142

< 0.001

 Optimal

23.3%

96/128 (75%)

    
  1. Characters in bold indicate statistical significance
  2. Abbreviations: DFS disease free survival, LN lymph node, CRS cytoreductive surgery
  3. a5-year recurrence free survival rate
  4. bThe number of cases with recurrence or death whichever occurred first