Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study

Table 3 Mean ± SEM of total Protein, CAT, SOD, POD, T-BARS, GR, Cholesterol, Triglycerides, HDL-C, LDL-C and VLDL-C, Testosterone, Progesterone and Estradiol Concentrations in Control, PCOS, PCOS+Metformin and PCOS+Quercetin treated female rats after 21 Days of experiment

Parameters	Control	PCOS	PCOS + Metformin	PCOS + Quercetin
Total Protein (mg/g)	33.62 ± 0.52	27.22 ± 1.39 ^a*	31.50 ± 1.53	30.65 ± 0.95
CAT (u/mg)	33.64 ± 1.38	5.26 ± 0.12 ^a***	30.71 ± 0.94 ^b***	40.74 ± 0.75 ^{a bc*}
SOD (u/mg)	8.14 ± 0.14	5.26 ± 0.12 ^a***	6.79 ± 0.13 ^{a** b*}	9.16 ± 0.21^{a bc*}
POD (μM/min)	0.47 ± 0.02	1.25 ± 0.07 ^a***	0.98 ± 0.04 ^a**b	0.72 ± 0.04 ^{ab** c*}
TBARS (μmol/mg)	23.74 ± 0.34	32.28 ± 2.10 ^a**	30.83 ± 0.74 ^a*	25.10 ± 1.14 ^b*
GR (nmol/mg protein)	1.42 ± 0.03	1.20 ± 0.02 ^a***	1.27 ± 0.02^b**	1.39 ± 0.02 ^b**
Cholesterol (mg/dl)	55.41 ± 0.56	63.96 ± 0.69 ^a***	55.84 ± 0.80 ^b***	55.61 ± 1.26 ^b***
Triglycerides (mg/dl)	51.93 ± 0.63	68.06 ± 1.42 ^a***	58.60 ± 0.65 ^b***	56.07 ± 0.78 ^b***
HDL-C (mg/dl)	28.47 ± 0.18	22.19 ± 1.00 ^a***	25.74 ± 0.17 ^ab*	23.97 ± 0.11 ^a***
LDL-C (mg/dl)	16.55 ± 0.51	26.95 ± 1.67 ^a***	20.37 ± 1.00 b^*	19.63 ± 1.14 ^b**
VLDL-C (mg/dl)	10.39 ± 0.13	13.73 ± 0.98 ^a*	11.72 ± 0.13	9.89 ± 0.27 ^b*
LDL-C/HDL-C	0.58 ± 0.02	1.63 ± 0.03 ^a***	0.72 ± 0.02 ^{a* b***}	0.63 ± 0.03 ^b***
TC/HDL-C	1.95 ± 0.02	3.36 ± 0.03 ^a**	2.17 ± 0.03 ^b**	1.72 ± 0.03 ^b***
TG/HDL-C	1.82 ± 0.02	2.69 ± 0.36	2.32 ± 0.06	2.15 ± 0.16
Testosterone (ng/ml)	0.38 ± 0.02	1.69 ± 0.17 ^a***	0.52 ± 0.11 ^b***	0.78 ± 0.14 ^b***
Progesterone (ng/ml)	39.65 ± 2.28	11.08 ± 1.17 ^a***	33.87 ± 2.96 ^b***	34.47 ± 1.65 ^b***
Estradiol (pg/ml)	9.29 ± 0.32	1.61 ± 0.29 ^a***	9.24 ± 0.59 ^b***	8.85 ± 0.19 ^b***

Values are expressed as Mean ± SEM
*, **, *** indicate significance from the control group at P < 0.001, 0.01 and 0.05 probability level
^aValue vs control, ^bValue vs PCOS and ^cValue vs PCOS+Metformin

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