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Fig. 5 | Journal of Ovarian Research

Fig. 5

From: MicroRNA-424/503 cluster members regulate bovine granulosa cell proliferation and cell cycle progression by targeting SMAD7 gene through activin signalling pathway

Fig. 5

Overexpression of the miR-424/503 cluster members enhanced cell cycle progression of bovine granulosa cells. Flow cytometric analysis showing the cell cycle distribution (G1/G0, S and G2/M phases) of propidium iodide (PI)-labeled bovine granulosa cells transfected with the mimic negative control (NC) (a), miR-424 mimic (b), miR-503 mimic (c), inhibitor NC (d), miR-424 inhibitor (e), or miR-503 inhibitor (f). Bar graphs showing the percentages of cells in G1/G0, S and G2/M phases of the cell cycle after transfection with miR-424/503 cluster mimics (g), and inhibitors (h). The bar graphs indicate the mean ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001)

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