Table 1 The known contribution of defective DNA repair pathways to ovarian cancer
From: DNA damage repair in ovarian cancer: unlocking the heterogeneity
DNA repair pathway | Type of repair | Contribution to serous ovarian cancer | Contribution to all histological subtypes of ovarian cancer |
|---|---|---|---|
Homologous Recombination | Double Strand Breaks | 50% [4] | 50% |
Non Homologous Enjoining | Double Strand Breaks | ||
Base Excision Repair | Nucleotide Excision and Single Strand Breaks | Polymorphisms and altered expression of BER components in 63–67% ovarian cancers [60, 91] | |
Mismatch Repair | Single Strand Breaks, Nucleotide Mismatches | 0.18% [94] | 0.76% [94], mostly clear cell |
Nucleotide Excision Repair | Single Strand Breaks, Bulky Lesions | 8% |